Quality of life among postmenopausal women enrolled in the Minnesota Green Tea Trial.
Quality of life among postmenopausal women enrolled in the Minnesota Green Tea Trial.
复制标题
参加明尼苏达绿茶试验的绝经后妇女的生活质量。
DOI：
10.1016/j.maturitas.2017.10.013
复制
发表时间：
2018
期刊：
影响因子：
4.9
通讯作者：
Torkelson,CarolynJ
中科院分区：
文献类型：
--
作者：
Webster,AllisonDostal;Finstad,DeborahA;Kurzer,MindyS;Torkelson,CarolynJ
背景绝经后症状尚未在大型长期人体临床试验中得到阐明。我们的目标是衡量 50-70 岁绝经后女性的生活质量。方法 参加明尼苏达绿茶试验的女性 (n = 932) 填写了更年期特定生活质量干预 (MENQOL) 问卷，以评估绝经后几年的血管舒缩、身体、性和心理社会症状。响应被编码；平均总体得分和领域得分范围为 1 至 8。得分越高表示症状越严重。结果平均总体 MENQOL 得分在 50-54.9 岁的女性中最高。总体上以及在每个领域内都观察到症状严重程度随着年龄的增加而降低的模式。 50-54.9岁的女性比其他年龄组的女性盗汗和出汗更严重（P≤0.001），并且比≥60岁的女性更严重的潮热（P≪0.001）。不同年龄组之间在性方面的平均得分没有差异。与 50.0-54.9 岁的女性（参考组）相比，60-64.9 岁和≥65 岁的研究参与者在心理社会领域的 MENQOL 得分较低（P=0.029 和 P≪0.001）。 50-54.9岁的女性与≥65岁的女性相比，与负面情绪相关的症状更严重（P≤0.009）。与50-54.9岁女性相比，60-64.9岁和≥65岁的女性“记忆力差”得分较低（2.98±1.75和2.66±1.68 vs. 3.43±1.87，P≪0.001）。与所有其他年龄组相比，≥ 65 岁的女性在“感到疲倦或疲惫”、“睡眠困难”和“缺乏精力”方面的得分较低 (P≤0.003)。 结论 这项对绝经后女性的描述性分析的结果可能有助于临床医生就解决更年期相关症状的期望和治疗方案以及绝经后症状与整体健康之间的关系向女性提供建议。
BackgroundPostmenopausal symptomatology has not been elucidated in large, long-term human clinical trials. Our objective was to measure quality of life in postmenopausal women aged 50–70 years.MethodsA Menopause-Specific Quality of Life-Intervention (MENQOL) questionnaire was completed by women enrolled in the Minnesota Green Tea Trial (n = 932) to assess vasomotor, physical, sexual, and psychosocial symptoms in the years following menopause. Responses were coded; mean overall and domain scores ranged from 1 to 8. A higher score indicated more severe symptoms.ResultsMean overall MENQOL scores were highest in women aged 50–54.9 years. A pattern of reduced symptom severity with increasing age was observed overall and within each domain. Women aged 50–54.9 years had more severe night sweats and sweating than other age groups (P≤ 0.001) and more severe hot flashes than women aged ≥ 60 years (P≪ 0.001). No differences between age groups were seen on mean score in the Sexual domain. Compared with women aged 50.0–54.9 years (the reference group), study participants aged 60–64.9 and ≥ 65 years had lower MENQOL scores in the Psychosocial domain (P= 0.029 andP≪ 0.001). Women aged 50–54.9 years had more severe symptoms related to negative mood than women ≥65 years (P≤ 0.009). Compared with women aged 50–54.9 years, those in the age groups 60–64.9 and ≥ 65 years had lower scores for “poor memory” (2.98 ± 1.75 and 2.66 ± 1.68 vs. 3.43 ± 1.87,P≪ 0.001). Women ≥ 65 years reported lower scores for “feeling tired or worn out”, “difficulty sleeping”, and “lack of energy” than all other age groups (P≤ 0.003).ConclusionThe findings of this descriptive analysis of postmenopausal women may help clinicians counsel women about expectations and treatment options to address menopause-associated symptoms and the relationship between postmenopausal symptoms and overall health.