Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae
Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae
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DOI：
10.1016/j.bbrc.2011.05.008
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发表时间：
2011-06-03
影响因子：
3.1
通讯作者：
Lee, Cheol-Koo
中科院分区：
文献类型：
--
作者：
Choi, Joon-Seok;Choi, Kyung-Mi;Lee, Cheol-Koo
已知热量限制（CR）可以延长多种物种的寿命;然而，其机制仍不清楚。在这项研究中，我们发现，CR增强线粒体电子传递链（ETC）在转录和翻译水平。事实上，线粒体膜电位（MMP）增加CR，而且，无论年龄，整体活性氧（ROS）的产生减少CR。通过这些变化，细胞的总体生长速率在各种CR条件下得以维持，就像细胞在非限制条件下一样。所有这些数据都支持通过CR提高ETC的效率和容量，并且这种变化可能导致寿命延长。(C)2011 Elsevier Inc. All rights reserved.
Caloric restriction (CR) is known to extend lifespan in a variety of species; however, the mechanism remains unclear. In this study, we found that CR potentiated the mitochondrial electron transport chain (ETC) at both the transcriptional and translational levels. Indeed, mitochondrial membrane potential (MMP) was increased by CR, and, regardless of ages, overall reactive oxygen species (ROS) generation was decreased by CR. With these changes, overall growth rate of cells was maintained under various CR conditions, just like cells under a non-restricted condition. All of these data support increased efficiency and capacity of the ETC by CR, and this change might lead to extension of lifespan. (C) 2011 Elsevier Inc. All rights reserved.