Predicting the severity of intestinal graft-versus-host disease from leukotriene B4 levels after bone marrow transplantation
Predicting the severity of intestinal graft-versus-host disease from leukotriene B4 levels after bone marrow transplantation
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从骨髓移植后白三烯 B4 水平预测肠道移植物抗宿主病的严重程度
DOI：
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发表时间：
2000
影响因子：
4.8
通讯作者：
E. Kakishita
中科院分区：
文献类型：
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作者：
H. Takatsuka;S. Yamada;T. Okamoto;Y. Fujimori;H. Wada;N. Iwata;Akihisa Kanamaru;E. Kakishita
肠移植物抗宿主病（GVHD）产生类似于溃疡性结肠炎的临床表现和组织学变化，并且已经用用于溃疡性结肠炎的药物治疗。这两种情况在细胞因子的变化方面也彼此相似。因此，我们研究了白三烯B4水平，溃疡性结肠炎的危险因素，是否也是肠道GVHD的危险因素或预后指标。42例患者预处理后血清Leukotoriene B4水平与肠道GVHD分级显著相关（P < 0.01）。与骨髓移植后未发生严重肠道GVHD的患者相比，发生严重肠道GVHD的患者在再生障碍期的白细胞介素2和干扰素γ水平显著升高（P <0.01），恢复期肿瘤坏死因子-α水平升高（P < 0.0001），肿瘤坏死因子-α和干扰素-γ的显著升高与肠道GVHD的加重有关（P < 0.001）。这些发现表明溃疡性结肠炎和肠道GVHD的发病机制之间的相似性，并提高了白三烯B4可能是肠道GVHD的有用的预后指标的可能性。骨髓移植（2000）26，1313-1316。
Intestinal graft-versus-host disease (GVHD) produces clinical manifestations and histological changes resembling those of ulcerative colitis and has been treated with drugs which are used for ulcerative colitis. These two conditions also resemble each other with respect to changes of cytokines. Accordingly, we investigated whether the level of leukotriene B4, a risk factor for ulcerative colitis, was also a risk factor or prognostic indicator for intestinal GVHD. The pre-conditioning leukotoriene B4 level was significantly related to the grade of intestinal GVHD in 42 patients (P < 0.01). Compared with patients who did not develop severe intestinal GVHD after bone marrow transplantation, those who did had significantly higher interleukin-2 and interferon-γ levels during the aplastic phase (P <0.01), followed by higher tumor necrosis factor-α levels during the recovery phase (P < 0.0001), with significant elevation of tumor necrosis factor-α and interferon-γ occurring in association with exacerbations of intestinal GVHD (P < 0.001). These findings suggest a similarity between the pathogenesis of ulcerative colitis and intestinal GVHD and raise the possibility that leukotriene B4 may be a useful prognostic indicator for intestinal GVHD. Bone Marrow Transplantation (2000) 26, 1313–1316.
影响因子：
158.5
作者：
CHAO, NJ;SCHMIDT, GM;FORMAN, SJ
通讯作者：
FORMAN, SJ