Formation and repair of DNA-protein crosslink damage.
Formation and repair of DNA-protein crosslink damage.
复制标题
DNA-蛋白质交联损伤的形成和修复。
DOI：
10.1007/s11427-017-9183-4
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发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Klages-Mundt NL;Li L
DNA不断暴露于各种遗传毒性物质中，产生各种形式的DNA损伤。DNA-蛋白质交联（DPCs）——蛋白质与DNA链的共价连接——是最有害的DNA损伤形式之一，也是研究最不足的DNA损伤形式之一，它对转录和复制构成空间阻断。如果修复不当，这些损伤会导致突变、基因组不稳定和细胞死亡。DPCs可由内源性或环境致癌物和化疗药物引起。内源性，dpc通常是通过与醛的反应，以及通过在DNA上捕获各种酶的中间体而产生的。对DPC的蛋白质片段进行蛋白水解切割是去除病变的一般策略。这可以通过dpc特异性蛋白酶和和/或蛋白酶体介导的降解来实现。核苷酸切除修复和同源重组都参与修复DPCs，它们各自的作用可能取决于加合物的性质和大小。范可尼贫血途径也可能在处理DPC修复中间体中起作用。在这篇综述中，我们讨论了这些病变是如何形成的，它们的清除策略和机制，以及与DPC修复缺陷相关的疾病。
DNA is constantly exposed to a wide array of genotoxic agents, generating a variety of forms of DNA damage. DNA-protein crosslinks (DPCs) – the covalent linkage of proteins with a DNA strand – are one of the most deleterious and understudied forms of DNA damage, posing as steric blockades to transcription and replication. If not properly repaired, these lesions can lead to mutations, genomic instability, and cell death. DPCs can be induced endogenously or through environmental carcinogens and chemotherapeutic agents. Endogenously, DPCs are commonly derived through reactions with aldehydes, as well as through trapping of various enzymatic intermediates onto the DNA. Proteolytic cleavage of the protein moiety of a DPC is a general strategy for removing the lesion. This can be accomplished through a DPC-specific protease and and/or proteasome-mediated degradation. Nucleotide excision repair and homologous recombination are each involved in repairing DPCs, with their respective roles likely dependent on the nature and size of the adduct. The Fanconi anemia pathway may also have a role in processing DPC repair intermediates. In this review, we discuss how these lesions are formed, strategies and mechanisms for their removal, and diseases associated with defective DPC repair.
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影响因子：
64.5
作者：
Duxin JP;Dewar JM;Yardimci H;Walter JC
通讯作者：
Walter JC
DOI：
10.1016/j.mrfmmm.2008.11.008
发表时间：
2009-03-09
影响因子：
2.3
作者：
Garcia, Claudia Lorenti;Mechilli, Manuela;Palitti, Fabrizio
通讯作者：
Palitti, Fabrizio
影响因子：
4.8
作者：
Baker, David J.;Wuenschell, Gerald;O'Connor, Timothy R.
通讯作者：
O'Connor, Timothy R.
DOI：
10.1016/0027-5107(82)90291-3
发表时间：
1982-01-01
期刊：
MUTATION RESEARCH
影响因子：
--
作者：
FORNACE, AJ;SERES, DS
通讯作者：
SERES, DS
影响因子：
16
作者：
Centore, Richard C.;Yazinski, Stephanie A.;Tse, Alice;Zou, Lee
通讯作者：
Zou, Lee