Markers of gluten sensitivity and celiac disease in bipolar disorder
Markers of gluten sensitivity and celiac disease in bipolar disorder
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DOI：
10.1111/j.1399-5618.2011.00894.x
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发表时间：
2011-02-01
影响因子：
5.4
通讯作者：
Yolken, Robert
中科院分区：
文献类型：
--
作者：
Dickerson, Faith;Stallings, Cassie;Yolken, Robert
目的：在精神分裂症中有报道说对饮食麸质蛋白的免疫敏感性增加，但在双相情感障碍中还没有研究。在这项研究中，我们研究的抗体反应性麦醇溶蛋白，脱酰胺麦醇溶蛋白，和组织转氨酶（tTG）在个人与双相情感障碍和比较这些水平的个人谁没有任何历史的精神disorder.Methods：275个人的样本包括102双相情感障碍和173个控制没有精神疾病。用酶免疫法测定抗麦醇溶蛋白的IgG和IgA抗体以及抗脱酰胺麦醇溶蛋白的tTG和IgG抗体。参与者的脱酰胺麦醇溶蛋白和tTG抗体水平根据预测乳糜泻的阳性截止值进行分类。定量水平的抗体进行了比较组间采用回归模型，控制人口统计学variables.Results：双相情感障碍的个人有增加的IgG抗体麦醇溶蛋白的水平相比，在多变量分析中的控制。我们还发现双相情感障碍人群中脱酰胺醇溶蛋白抗体水平增加的证据。伊加类抗麦胶蛋白抗体和tTG抗体的水平在组间没有显著差异。也有没有一个显着差异的人数被归类为具有抗体水平的脱酰胺醇溶蛋白或tTG是预测腹腔diseases.Conclusions：双相情感障碍的个人有增加的IgG抗体水平的醇溶蛋白。然而，这种抗体的增加并不伴随着IgA抗体的麦醇溶蛋白或乳糜泻相关的抗体对脱酰胺麦醇溶蛋白和tTG的升高。这些结果保证了进一步详细的分子特异性和双相情感障碍中谷蛋白抗原的抗体反应模式的检查。
Objectives:Increased immune sensitivity to dietary gluten proteins has been reported in schizophrenia but has not been studied in bipolar disorder. In this study, we examine the levels of antibody reactivity to gliadin, deamidated gliadin, and tissue transglutaminase (tTG) in individuals with bipolar disorder and compare these levels to those in individuals who do not have any history of psychiatric disorder.Methods:The sample of 275 individuals included 102 with bipolar disorder and 173 controls without a psychiatric disorder. Immunoglobulin G (IgG) and immunoglobulin A (IgA) antibodies to gliadin and tTG and IgG antibodies to deamidated gliadin were measured by enzyme immunoassay. Participants' levels of antibodies to deamidated gliadin and tTG were classified based on the cutoffs for positivity that are predictive of celiac disease. Quantitative levels of antibodies were compared between groups employing regression models which were controlled for demographic variables.Results:Individuals with bipolar disorder had increased levels of IgG antibodies to gliadin compared with controls in multivariate analyses. We also found evidence of increased levels of antibodies to deamidated gliadin in the bipolar disorder population. The levels of IgA class antigliadin antibodies and antibodies to tTG did not differ significantly between groups. There was also not a significant difference between groups in the number of persons who were classified as having levels of antibodies to deamidated gliadin or tTG that are predictive of celiac disease.Conclusions:Individuals with bipolar disorder have increased levels of IgG antibodies to gliadin. However, such antibody increase is not accompanied by an elevation in IgA antibodies to gliadin or the celiac disease-associated antibodies against deamidated gliadin and tTG. These results warrant further detailed examination of the molecular specificity and pattern of reactivity of the antibody response to gluten antigens in bipolar disorder.