INVASIVE FUNGAL DISEASE IN ADULTS UNDERGOING REMISSION-INDUCTION THERAPY FOR ACUTE MYELOID-LEUKEMIA - THE PATHOGENETIC ROLE OF THE ANTILEUKEMIC REGIMEN
INVASIVE FUNGAL DISEASE IN ADULTS UNDERGOING REMISSION-INDUCTION THERAPY FOR ACUTE MYELOID-LEUKEMIA - THE PATHOGENETIC ROLE OF THE ANTILEUKEMIC REGIMEN
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DOI：
10.1093/clinids/21.2.361
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发表时间：
1995-08-01
影响因子：
11.8
通讯作者：
SCHACTER, B
中科院分区：
文献类型：
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作者：
BOW, EJ;LOEWEN, R;SCHACTER, B
采用多变量技术，我们研究了138例接受诱导治疗的未经治疗的急性髓性白血病（AML）患者的侵袭性真菌病发病机制中细胞毒性方案，肠粘膜损伤和真菌定植的关系，根据三个机构方案：AML-84（阿糖胞苷/柔红霉素），AML-87（高剂量阿糖胞苷/依托泊苷/柔红霉素）和AML-88（米托蒽醌/依托泊苷）。在AML-87、AML-84和AML-88方案的患者中，侵袭性真菌病的发生率分别为36%、6%和2.6%（χ 2 = 23.465; P
Using multivariate techniques, we studied the relationships of cytotoxic regimen, intestinal mucosal damage, and fungal colonization in the pathogenesis of invasive fungal disease in 138 patients undergoing induction therapy for untreated acute myeloid leukemia (AML) according to three institutional protocols: AML-84 (cytarabine/daunorubicin), AML-87 (high-dose cytarabine/etoposide/daunorubicin), and AML-88 (mitoxantrone/etoposide). Invasive fungal disease occurred in 36%, 6%, and 2.6% of patients participating in protocols AML-87, AML-84, and AML-88, respectively (chi(2) = 23.465; P