Prevalence of Streptococcal Pharyngitis and Streptococcal Carriage in Children: A Meta-analysis
Prevalence of Streptococcal Pharyngitis and Streptococcal Carriage in Children: A Meta-analysis
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DOI：
10.1542/peds.2009-2648
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发表时间：
2010-09-01
期刊：
影响因子：
8
通讯作者：
Martin, Judith M.
中科院分区：
文献类型：
--
作者：
Shaikh, Nader;Leonard, Erica;Martin, Judith M.
目的：患病率估计可以帮助临床医生做出明智的决定，关于诊断测试的儿童谁目前与症状的咽炎。我们进行了一项荟萃分析，以确定（1）链球菌感染的患病率在儿童谁提出的咽喉痛和（2）链球菌携带的患病率在无症状的children.METHODS：我们搜索Medline的文章儿科链球菌咽炎。我们在综述中纳入了包含18岁以下儿童咽部标本中A组链球菌（GAS）患病率数据的文章。两名评价者独立审查、评级并从每篇文章中提取数据。流行率估计汇总在荟萃分析和分层根据年龄group.RESULTS：检索到的266篇文章，29符合所有纳入标准。在所有年龄段出现咽喉痛的儿童中，GAS的合并患病率为37%（95%置信区间[CI]：32%-43%）。5岁以下儿童的GAS患病率较低（24% [95% CI：21%-26%]）。GAS携带的患病率为12%（95%CI：9%-14%），良好的儿童没有咽炎的体征或症状。结论：GAS疾病和携带的患病率因年龄而异;年龄小于5岁的儿童咽喉培养GAS阳性率较低。儿科2010;126：e557-e564
OBJECTIVES: Prevalence estimates can help clinicians make informed decisions regarding diagnostic testing of children who present with symptoms of pharyngitis. We conducted a meta-analysis to determine the (1) prevalence of streptococcal infection among children who presented with sore throat and (2) prevalence of streptococcal carriage among asymptomatic children.METHODS: We searched Medline for articles on pediatric streptococcal pharyngitis. We included articles in our review when they contained data on the prevalence of group A Streptococcus (GAS) from pharyngeal specimens in children who were younger than 18 years. Two evaluators independently reviewed, rated, and abstracted data from each article. Prevalence estimates were pooled in a meta-analysis and stratified according to age group.RESULTS: Of the 266 articles retrieved, 29 met all inclusion criteria. Among children of all ages who present with sore throat, the pooled prevalence of GAS was 37% (95% confidence interval [CI]: 32%-43%). Children who were younger than 5 years had a lower prevalence of GAS (24% [95% CI: 21%-26%]). The prevalence of GAS carriage among well children with no signs or symptoms of pharyngitis was 12% (95% CI: 9%-14%).CONCLUSIONS: Prevalence rates of GAS disease and carriage varied by age; children who were younger than 5 years had lower rates of throat cultures that were positive for GAS. Pediatrics 2010;126:e557-e564