Abnormal microstructures of the basal ganglia in schizophrenia revealed by diffusion tensor imaging
Abnormal microstructures of the basal ganglia in schizophrenia revealed by diffusion tensor imaging
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DOI：
10.1080/15622970701762536
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发表时间：
2009-01-01
影响因子：
3.1
通讯作者：
Ohnishi, Takashi
中科院分区：
文献类型：
--
作者：
Hashimoto, Ryota;Mori, Takeyuki;Ohnishi, Takashi
有一种假说认为，基底神经节-丘脑系统的缺陷可能在精神分裂症患者目标导向行为功能障碍中起重要作用。利用弥散张量成像技术，我们测量了42名精神分裂症患者和42名对照者基底神经节-丘脑系统的分数各向异性（FA）值，以研究精神分裂症患者基底神经节-丘脑系统的微结构组织改变。与对照组相比，精神分裂症患者双侧苍白球和左侧丘脑的FA值明显降低，这表明精神分裂症患者可能在苍白球和丘脑中存在微观结构异常。这些数据支持了基底神经节-丘脑系统髓鞘形成异常与精神分裂症病理生理相关的观点。
There has been a hypothesis that deficits in the basal ganglia-thalamic system may play an important role in the dysfunctional goal-directed behaviour in schizophrenia. By using diffusion tensor imaging, we measured fractional anisotropy (FA) values in the basal ganglia-thalamic system in 42 schizophrenics and 42 matched controls to investigate microstructural tissue alterations in the basal ganglia-thalamic system in schizophrenia. Schizophrenics had significantly lower FA values in the bilateral globus pallidus and left thalamus compared to controls, suggesting that schizophrenics might have microstructural abnormalities in globus pallidus and thalamus. These data support the notion that myelination abnormalities in basal ganglia-thalamic system are related to the pathophysiology of schizophrenia.