Current Trends in Viral Gene Therapy for Human Orthopaedic Regenerative Medicine
Current Trends in Viral Gene Therapy for Human Orthopaedic Regenerative Medicine
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DOI：
10.1007/s13770-019-00179-x
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发表时间：
2019-02
影响因子：
3.6
通讯作者：
J. Venkatesan;A. Rey-Rico;M. Cucchiarini
中科院分区：
文献类型：
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作者：
J. Venkatesan;A. Rey-Rico;M. Cucchiarini
背景基于病毒载体的治疗性基因治疗是增强人类骨科组织固有修复能力的有效策略。然而，病毒基因转移的临床应用仍然受到宿主对这些载体的有害反应(免疫原性反应，载体传播到非靶点位置)的阻碍。将病毒基因治疗技术与组织工程技术相结合，可能为改进现有的活体应用系统提供强有力的工具。方法本工作的目的是综述在人类骨科再生医学中利用生物材料技术和治疗性病毒基因转移的最新系统。结果组织工程平台与病毒基因载体的集成是骨科研究的一个活跃领域，是克服有效病毒基因治疗障碍的一种手段。结论鉴于在不久的将来可能迅速扩大的前景良好的临床前数据，生物材料引导的病毒基因治疗在人类骨科再生医学领域具有很强的翻译潜力。
BackgroundViral vector-based therapeutic gene therapy is a potent strategy to enhance the intrinsic reparative abilities of human orthopaedic tissues. However, clinical application of viral gene transfer remains hindered by detrimental responses in the host against such vectors (immunogenic responses, vector dissemination to nontarget locations). Combining viral gene therapy techniques with tissue engineering procedures may offer strong tools to improve the current systems for applicationsin vivo.MethodsThe goal of this work is to provide an overview of the most recent systems exploiting biomaterial technologies and therapeutic viral gene transfer in human orthopaedic regenerative medicine.ResultsIntegration of tissue engineering platforms with viral gene vectors is an active area of research in orthopaedics as a means to overcome the obstacles precluding effective viral gene therapy.ConclusionsIn light of promising preclinical data that may rapidly expand in a close future, biomaterial-guided viral gene therapy has a strong potential for translation in the field of human orthopaedic regenerative medicine.