Rapid evolution of the male-specific antibacterial protein andropin gene in Drosophila
Rapid evolution of the male-specific antibacterial protein andropin gene in Drosophila
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DOI：
10.1007/s00239-001-0062-5
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发表时间：
2002-05-01
影响因子：
3.9
通讯作者：
Chigusa, SI
中科院分区：
文献类型：
--
作者：
Date-Ito, A;Kasahara, K;Chigusa, SI
编码抗菌蛋白的雄激素与D.黑腹菌Andropin和Cecropins被认为起源于一个共同的祖先。然而，雄激素的表达模式与天蚕素不同，仅限于成年雄性射精管。为了阐明Andropin的进化过程，我们对D.黑腹果蝇及其近缘种。In D.在黑腹果蝇中，与天蚕素相比，雄激素的核苷酸多样性显著较低。与此相反，雄激素的非同义取代是显着频繁的物种之间。从基因组Southern分析，雄激素样基因存在于至少黑腹物种亚组。目前的一系列结果表明，Andropin是在构建果蝇天蚕素基因家族的过程中产生的，然后开始迅速进化，与天蚕素相反。
Andropin, which encodes an antibacterial protein, is closely linked to the Cecropin gene cluster of D. melanogaster. Andropin and Cecropins are considered to have originated from one common ancestor. However, the expression pattern of Andropin is distinct from that of Cecropins, being restricted to the adult male ejaculatory duct. To elucidate the evolutionary process of Andropin, we have sequenced Androl in genes from D. melanogaster and its closely related species. In D. melanogaster, the nucleotide diversity of Andropin is remarkably low compared to that of Cecropin. In contrast, nonsynonymous substitutions of Andropin are conspicuously frequent between species. From genomic Southern analysis, Andropin-like genes are present in at least the melanogaster species subgroup. The series of present results suggests that Andropin was born in the course of constructing the Drosophila Cecropin gene family and then started to evolve rapidly, in contrast to Cecropins.