Oxidative stress: changes in pregnancy and with gestational diabetes mellitus.
Oxidative stress: changes in pregnancy and with gestational diabetes mellitus.
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DOI：
10.1007/s11892-005-0024-1
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发表时间：
2005-08-01
影响因子：
4.2
通讯作者：
Scholl, Theresa O
中科院分区：
文献类型：
--
作者：
Chen, Xinhua;Scholl, Theresa O
妊娠易受氧化应激的影响，抗氧化防御系统可能会因氧化应激水平升高而改变。妊娠期糖尿病（GDM）的有限数据表明，脂质过氧化产物可能增加，抗氧化酶活性降低，尽管结果不一致。与2型糖尿病（T2DM）一样，GDM患者的血糖水平与脂质过氧化物浓度相关。补充抗氧化剂或富含抗氧化剂的食物对T2DM的影响存在争议。是否增加抗氧化剂的摄入量可以减少GDM的并发症在母亲和胎儿还没有探讨。
Pregnancy is susceptible to oxidative stress and antioxidant defenses can be altered in response to elevated levels of oxidative stress. Limited data in gestational diabetes mellitus (GDM) suggest that products of lipid peroxidation may be increased and antioxidant enzyme activities decreased, although the results have been inconsistent. As in type 2 diabetes mellitus (T2DM), glycemic levels in patients with GDM correlate with concentrations of lipid peroxides. The effects of supplementation with antioxidants or antioxidant-rich food in T2DM are controversial. Whether or not increased antioxidant intake can reduce the complications of GDM in both mother and fetus has not been explored.