Gene-diet quality interactions on haemoglobin A1c and type 2 diabetes risk: The Airwave Health Monitoring Study
Gene-diet quality interactions on haemoglobin A1c and type 2 diabetes risk: The Airwave Health Monitoring Study
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DOI：
10.1002/edm2.74
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发表时间：
2019-10-01
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影响因子：
--
通讯作者：
Frost, Gary
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作者：
Eriksen, Rebeca;Gibson, Rachel;Frost, Gary
2型糖尿病（T2D）是多因素的，涉及生活方式、环境和遗传等危险因素。本研究旨在调查基因与酒精和饮食质量的相互作用对英国人群中独立于肥胖的糖化血红蛋白A1c （HbA1c）的影响。方法：对来自电波健康监测研究的14089名英国白人参与者进行横断面研究，并对3733名有饮食数据的参与者进行亚样本研究。构建T2D遗传风险评分（GRS），并评估其与饮食对HbA1c的影响。结果：GRS与较高的HbA1c% （β = 0.03, P < 0.0001）、较高的糖尿病前期（OR = 1.09, P < 0.0001）和T2D （OR = 1.14, P = 0.006）相关。遗传对HbA1c%的影响在肥胖参与者中显著更高（β = 1.88， p -交互作用= 0.03）。在高危人群中，大量摄入全麦食品可降低HbA1c%的影响，p相互作用= 0.04。结论：与体重正常的人相比，基因对肥胖个体HbA1c的影响几乎翻了一番，并且与体重无关，高遗传风险个体食用高全麦饮食的HbA1c有适度的抵消。这支持了在高遗传风险人群中，健康饮食和保持健康体重对于控制HbA1c的重要性。
Introduction: Type 2 diabetes (T2D) is multifactorial involving lifestyle, environmental and genetic risk factors. This study aims to investigate the impact of genetic interactions with alcohol and diet quality on glycated haemoglobin A1c (HbA1c) independent of obesity, in a British population. Methods: Cross-sectional study of 14 089 white British participants from Airwave Health Monitoring Study and a subsample of 3733 participants with dietary data. A T2D genetic risk score (GRS) was constructed, and its interactions with diet on HbA1c were assessed. Results: GRS was associated with a higher HbA1c% (beta = 0.03, P < 0.0001) and a higher risk of prediabetes (OR = 1.09, P < 0.0001) and T2D (OR = 1.14, P = 0.006). The genetic effect on HbA1c% was significantly higher in obese participants (beta = 1.88, P-interaction = 0.03). A high intake of wholegrain attenuated the effect on HbA1c% in high-risk individuals P-interaction = 0.04. Conclusion: The genetic effect on HbA1c was almost doubled in obese individuals, compared with those with a healthy weight, and independent of weight, there was a modest offset on HbA1c in high-genetic-risk individuals consuming a diet high in wholegrain. This supports the importance of a healthy diet high in wholegrains and along with maintaining a healthy weight in controlling HbA1c among high-genetic-risk groups.