The Utility of Menstrual Cycle Length as an Indicator of Cumulative Hormonal Exposure
The Utility of Menstrual Cycle Length as an Indicator of Cumulative Hormonal Exposure
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DOI：
10.1210/jc.2012-1350
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发表时间：
2012-10-01
影响因子：
5.8
通讯作者：
Schisterman, Enrique F.
中科院分区：
文献类型：
--
作者：
Mumford, Sunni L.;Steiner, Anne Z.;Schisterman, Enrique F.
背景：月经周期长度与慢性疾病之间的关联被假设是由于潜在激素模式的差异。目的：本研究的目的是评估月经周期长度与激素水平和无排卵的关系。设计与环境：我们于2005年至2007年在布法罗大学进行了一项前瞻性队列研究。参与者：我们招募了259名年龄在18-44岁的健康、月经规律的女性。主要结果测量：观察周期长度最多为两个周期。血清雌二醇、黄体酮、黄体生成素和卵泡刺激素每周期测量8次，持续2个周期。结果：周期短（35 d）的女性，雌二醇和LH峰平均比周期正常的女性晚3 d， FSH峰平均晚1 d。与正常长度的周期相比，短周期和长周期都增加了无排卵的可能性。一般来说，根据曲线下的面积，短周期的女性每周期接触到的激素较少，尽管随着时间的推移，短周期的女性累积接触到的雌二醇会更多。结论：较短的排卵周期与较高的卵泡期雌二醇、较早的FSH升高和无排卵风险增加有关。这些结果表明，月经周期长度可能是雌二醇暴露和月经周期正常女性无排卵风险的相关指标。[J] .中华内分泌杂志，2012,31(5):379 - 379。
Context: Associations between menstrual cycle length and chronic diseases are hypothesized to be due to differences in underlying hormonal patterns.Objective: The aim of the study was to evaluate the association between menstrual cycle length and the hormonal profile and anovulation.Design and Setting: We conducted a prospective cohort study at the University at Buffalo from 2005 to 2007.Participants: We recruited 259 healthy, regularly menstruating women aged 18-44 yr.Main Outcome Measures: Cycle length was observed for up to two cycles. Serum estradiol, progesterone, LH, and FSH were measured up to eight times per cycle for up to two cycles.Results: Women with short cycles (35 d), estradiol and LH peaks occurred on average about 3 d later, and FSH peaks about 1 d later compared to women with normal-length cycles. Both short and long cycles, compared with normal-length cycles, had an increased probability of anovulation. In general, per-cycle exposure to hormones was less in short cycles based on the area under the curve, although over time the cumulative exposure to estradiol would be greater for women with short cycles.Conclusions: Short ovulatory cycles were associated with higher follicular phase estradiol, an earlier rise in FSH, and an increased risk of anovulation. These results suggest that menstrual cycle length may be a relevant indicator of estradiol exposure and risk of anovulation among regularly cycling women. (J Clin Endocrinol Metab 97: E1871-E1879, 2012)