Association between periodontal disease and acute myocardial infarction
Association between periodontal disease and acute myocardial infarction
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DOI：
10.1902/jop.2000.71.12.1882
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发表时间：
2000-12-01
影响因子：
4.3
通讯作者：
Atilla, G
中科院分区：
文献类型：
--
作者：
Emingil, G;Buduneli, E;Atilla, G
背景：冠心病是世界范围内发病率和死亡率最高的疾病。众所周知的危险因素独立或联合参与心肌梗死和动脉粥样硬化。最近的数据表明，病毒和细菌感染也可能导致急性血栓栓塞事件。为探讨急性心肌梗死（AMI）和慢性冠心病（CCHD）患者牙周健康状况与冠心病的关系，选择急性心肌梗死（AMI）和慢性冠心病（CCHD）患者各60例。AMI组患者（50名男性和10名女性;平均年龄53.8 ± 9.5岁）因AMI入住埃格大学医院心脏科。CCHD患者组（42名男性和18名女性;平均年龄58.5 ± 11.6岁）没有记录的近期急性冠状动脉事件史。所有患者均接受了临床检查并完成了医疗问卷。记录牙齿缺失、牙列缺损、探诊深度（PD）和探诊出血（BOP）。入院时采集血样，测定血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇（HDL-胆固醇）、低密度脂蛋白胆固醇（LDL-胆固醇）和空腹血糖水平。样本比例比较采用卡方检验，定量变量比较采用Student t检验。结果：AMI组与CCHD组间PD ≥ 4 mm的部位数、BOP部位百分率、吸烟状况、总胆固醇、LDL-胆固醇、甘油三酯差异有统计学意义（P < 0.05）。Logistic回归分析显示，牙周病与急性心肌梗死的关系与牙周病的发生部位、牙周病4级的发生部位、牙周病的发生次数、吸烟情况、甘油三酯水平有关（P < 0.05）。据我们所知，这是第一个研究，报告牙周健康的重要性，发生急性心肌梗死在土耳其人口。我们建议，前瞻性随机研究，以确定牙周病是否是急性心肌梗死发生的危险因素。
Background: Coronary heart disease is the leading cause of morbidity and mortality throughout the world. Well-known risk factors independently or combined participate in both myocardial infarction and atherosclerosis. Recent data have shown that viral and bacterial infections may also contribute to the acute thromboembolic events. The aim of the present study was to investigate the possible association between periodontal health and coronary heart disease in patients with acute myocardial infarction and chronic coronary heart disease.Methods: A total of 120 patients, 60 with acute myocardial infarction (AMI) and 60 with chronic coronary heart disease (CCHD) were included in this study. The patients in the AMI group (50 men and 10 women; mean age 53.8 +/- 9.5 years) were admitted to the Department of Cardiology, University Hospital of Ege because of AMI. The CCHD patients group (42 men and 18 women; mean age 58.5 +/- 11.6 years) had no documented history of recent acute coronary events. All patients were clinically examined and completed a medical questionnaire. Missing teeth, restorations, probing depth (PD) and bleeding on probing (BOP) were recorded. Blood samples were taken on admission for measurements of serum total cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-cholesterol), low density lipoprotein cholesterol (LDL-cholesterol), and fasting blood glucose level. Sample proportions were compared by chi square test, quantitative variables with Student t test. The relation of clinical parameters and conventional risk factors to AMI was assessed with logistic regression analysis.Results: The number of sites with PD greater than or equal to4 mm, the percentage of sites exhibiting BOP, smoking status, total cholesterol, LDL-cholesterol, and triglycerides were statistically different between AMI and CCHD groups (P < 0.05). Logistic regression analysis showed that the percentage of sites exhibiting BOP, the number of sites with PD 4, the number of restorations, smoking status, and triglycerides levels were significantly associated with AMI (P < 0.05).Conclusions: The results of this study indicate that periodontal disease may be associated with acute myocardial infarction. To our knowledge, this is the first study that reports the importance of periodontal health in the occurrence of acute myocardial infarction in a Turkish population. We propose that prospective randomized studies are needed to determine whether periodontal disease is a risk factor in the occurrence of acute myocardial infarction.