Life events and borderline personality features: the influence of gene-environment interaction and gene-environment correlation
Life events and borderline personality features: the influence of gene-environment interaction and gene-environment correlation
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DOI：
10.1017/s0033291710001297
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发表时间：
2011-04-01
影响因子：
6.9
通讯作者：
Boomsma, D. I.
中科院分区：
文献类型：
--
作者：
Distel, M. A.;Middeldorp, C. M.;Boomsma, D. I.
背景。创伤性生活事件通常在边缘型人格障碍（BPD）患者中比非边缘型人格障碍患者或其他人格障碍患者更常见。本研究探讨生活事件暴露是否会调节BPD特征的遗传结构。由于基因型-环境相关性（r(GE)）的存在可能导致基因型-环境相互作用（gxe）的错误发现，我们也测试了BPD特征是否增加了暴露于生活事件的可能性。用人格评估量表-边缘特征量表（PAI-BOR）评估个体患BPD的风险程度。被研究的生活事件包括离婚/分手、交通事故、暴力袭击、性侵犯、抢劫和失业。数据来自5083对双胞胎和1285对非双胞胎兄弟姐妹。采用结构方程模型（SEM）和双胎对照设计评估基因与环境的相互作用和相关性。有证据表明基因-环境相互作用和相关。累加性遗传对BPD特征的影响与性侵犯暴露相互作用，暴露个体的遗传变异较低。在经历过离婚/分手、暴力袭击、性侵犯或失业的个体中，BPD特征的环境方差较高，导致暴露个体BPD特征的遗传力较低。在一些生活事件中存在基因与环境的相关性。因此，影响BPD特征的基因也增加了暴露于某些生活事件的可能性。据我们所知，这项研究首次测试了遗传和环境影响以及生活事件暴露对普通人群BPD特征的共同影响。我们的研究结果表明，遗传脆弱性和生活事件都很重要。
Background. Traumatic life events are generally more common in patients with borderline personality disorder (BPD) than in non-patients or patients with other personality disorders. This study investigates whether exposure to life events moderates the genetic architecture of BPD features. As the presence of genotype-environment correlation (r(GE)) can lead to spurious findings of genotype-environment interaction (G x E), we also test whether BPD features increase the likelihood of exposure to life events.Method. The extent to which an individual is at risk to develop BPD was assessed with the Personality Assessment Inventory - Borderline features scale (PAI-BOR). Life events under study were a divorce/break-up, traffic accident, violent assault, sexual assault, robbery and job loss. Data were available for 5083 twins and 1285 non-twin siblings. Gene-environment interaction and correlation were assessed by using structural equation modelling (SEM) and the co-twin control design.Results. There was evidence for both gene-environment interaction and correlation. Additive genetic influences on BPD features interacted with the exposure to sexual assault, with genetic variance being lower in exposed individuals. In individuals who had experienced a divorce/break-up, violent assault, sexual assault or job loss, environmental variance for BPD features was higher, leading to a lower heritability of BPD features in exposed individuals. Gene-environment correlation was present for some life events. The genes that influence BPD features thus also increased the likelihood of being exposed to certain life events.Conclusions. To our knowledge, this study is the first to test the joint effect of genetic and environmental influences and the exposure to life events on BPD features in the general population. Our results indicate the importance of both genetic vulnerability and life events.