CYTOSKELETAL FUNCTIONS DURING DROSOPHILA OOGENESIS
CYTOSKELETAL FUNCTIONS DURING DROSOPHILA OOGENESIS
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DOI：
10.1126/science.7939713
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发表时间：
1994-10-28
期刊：
影响因子：
56.9
通讯作者：
THEURKAUF, WE
中科院分区：
文献类型：
--
作者：
COOLEY, L;THEURKAUF, WE
Organismal morphogenesis is driven by a complex series of developmentally coordinated changes in cell shape, size, and number. These changes in cell morphology are in turn dependent on alterations in basic cytoarchitecture. Elucidating the mechanisms of development thus requires an understanding of the cytoskeletal elements that organize the cytoplasm of differentiating cells. Drosophila oogenesis has emerged as a versatile system for the study of cytoskeletal function during development. A series of highly coordinated changes in cytoskeletal organization are required to produce a mature Drosophila oocyte, and these cytoskeletal transformations are amenable to a variety of experimental approaches. Genetic, molecular, and cytological studies have shed light on the specific functions of the cytoskeleton during oogenesis. The results of these studies are reviewed here, and their mechanistic implications are considered.
