Kinetics of bone growth into cylindrical channels in aluminum oxide and titanium.
Kinetics of bone growth into cylindrical channels in aluminum oxide and titanium.
复制标题
骨骼生长成氧化铝和钛圆柱形通道的动力学。
DOI：
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
K. Kirkland
中科院分区：
文献类型：
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作者：
P. Predecki;J. E. Stephan;B. A. Auslaender;V. Mooney;K. Kirkland
将不同表面粗糙度的致密氧化铝、致密多孔钛和表面氧化钛样品植入人体股骨内2-8周，这些样品含有直径为95-1000 μ的长圆柱形通道。钙化组织向这些通道内生长的深度主要是通过电子探针作为时间的函数来确定的。
Samples of dense aluminum oxide, dense, porous, and surface-oxidized titanium of varying surface roughness and containing long cylindrical channels 95–1000 μ in diameter were implanted in vivo in do femurs for periods of 2–8 weeks. The depth of ingrowth of calcified tissue into these channels was determined as a function of time, principally by electron microprobe.
The most rapid bone ingrowth was obtained with 500–, 525–, and 1000–μ diameter channels in all the titanium and aluminum oxide samples. However, the fraction of any given channel cross-section filled with bone was observed to decrease as the channel diameter increased. In these channels, ingrowth depths of more than 2000 μ were often achieved in 4 weeks after which the rate of ingrowth levelled off somewhat. A certain degree of surface rougheness (greater than 20 μ in. a.a.) appeared to be necessary for fixation and ingrowth. Ingrowth of bone into the 95-μ diameter channels was neglibile even after 18 weeks. The presence of interconnecting fine porosity per se, was found not essential for bone ingrowth nor does it have a major effect on ingrowth kinetics.