Rapid diagnosis of influenza infection in older adults: Influence on clinical care in a routine clinical setting
Rapid diagnosis of influenza infection in older adults: Influence on clinical care in a routine clinical setting
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DOI：
10.1016/j.jcv.2007.12.014
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发表时间：
2008-06-01
影响因子：
8.8
通讯作者：
Nichol, Kristin L.
中科院分区：
文献类型：
--
作者：
D'Heilly, Sarah J.;Janoff, Edward N.;Nichol, Kristin L.
背景：流感的实验室诊断以前依赖于培养中的病毒分离。快速抗原测试(大鼠)现已可用，但很少有研究在常规临床条件下考察其在老年人中的使用情况。目的：确定大鼠在大型医疗中心就诊的老年人中的效用以及测试结果如何影响临床护理。研究设计：对2003-2004年和2004-2005年流感季节进行流感测试的患者进行回顾性图表回顾。结果：84例成人流感检测呈阳性。将大鼠的结果添加到预测流感的症状复合体中，显著提高了在急性情况下诊断流感的能力。随着阳性率的增加，发热和咳嗽的阳性预测值从32%增加到92%。这只老鼠还指导了适当的抗病毒治疗。20/22(91%)阳性率和症状的患者
Background: Laboratory diagnosis of influenza has previously relied on viral isolation in culture. Rapid antigen tests (RATs) are now available but few studies have examined their use in older adults under routine clinical conditions.Objectives: To determine the utility of the RAT in older adults presenting to a large medical center and how test results impacted clinical care.Study design: Retrospective chart review of patients tested for influenza during the 2003-2004 and 2004-2005 influenza seasons. Clinical data were correlated with the results of laboratory testing.Results: Eighty-four adults tested positive for influenza. Adding the results of the RAT to symptom complexes predictive of influenza significantly enhanced the ability to diagnose influenza in the acute setting. The positive predictive value of fever plus cough increased from 32% to 92% with a positive RAT. The RAT also directed appropriate antiviral therapy. 20/22 (91%) patients with a positive RAT and symptoms