In vivo transcostal histotripsy therapy without aberration correction
In vivo transcostal histotripsy therapy without aberration correction
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DOI：
10.1088/0031-9155/59/11/2553
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发表时间：
2014-06-07
影响因子：
3.5
通讯作者：
Xu, Z.
中科院分区：
文献类型：
--
作者：
Kim, Y.;Vlaisavljevich, E.;Xu, Z.
本研究探讨了在体内的治疗能力，经肋组织碎石术，而不使用像差校正机制及其热影响覆盖组织。在8只猪中进行了非侵入性肝脏治疗，其中4个病变通过经肋窗产生，胸腔完全阻塞，4个病变通过经腹窗产生，肋骨没有覆盖。通过750 kHz聚焦换能器使用200 Hz PRF的5个周期脉冲进行治疗，估计原位峰值负压为13-17 MPa。用插入皮下表面的针形热电偶测量包括肋骨在内的覆盖组织的温度。施加约40分钟的处理，使覆盖的组织温度达到饱和。在经肋和经腹治疗中，病变产生的消融体积在统计学上相当，分别为3.6 +/- 1.7 cm（3）和4.5 +/- 2.0 cm（3）。在经肋处理中观察到的平均温度增加为3.9 +/- 2.1摄氏度，而经腹处理显示出1.7 +/- 1.3摄氏度的增加。在胸腔或其他覆盖组织上未观察到损伤。这些结果表明，组织摧毁术可以在体内通过胸腔实现有效的治疗，而不需要校正机制，同时不会引起对覆盖组织的实质性热效应或损伤。这种能力可以使涉及经肋治疗窗的几种非侵入性治疗应用受益。
This study investigates the in vivo therapeutic capabilities of transcostal histotripsy without using aberration correction mechanisms and its thermal impact on overlying tissues. Non-invasive liver treatments were conducted in eight pigs, with four lesions generated through transcostal windows with full ribcage obstruction and four lesions created through transabdominal windows without rib coverage. Treatments were performed by a 750 kHz focused transducer using 5 cycle pulses at 200 Hz PRF, with estimated in situ peak negative pressures of 13-17 MPa. Temperatures on overlying tissues including the ribs were measured with needle thermocouples inserted superficially beneath the skin. Treatments of approximately 40 min were applied, allowing overlying tissue temperatures to reach saturation. Lesions yielded statistically comparable ablation volumes of 3.6 +/- 1.7 cm(3) and 4.5 +/- 2.0 cm(3) in transcostal and transabdominal treatments, respectively. The average temperature increase observed in transcostal treatments was 3.9 +/- 2.1 degrees C, while transabdominal treatments showed an increase of 1.7 +/- 1.3 degrees C. No damage was seen on the ribcage or other overlying tissues. These results indicate that histotripsy can achieve effective treatment through the ribcage in vivo without requiring correction mechanisms, while inducing no substantial thermal effects or damage to overlying tissues. Such capabilities could benefit several non-invasive therapy applications involving transcostal treatment windows.