Simultaneous presentation of Kaposi sarcoma and HHV8-associated large B-cell lymphoma in the same lymph node: A rare diagnosis in an HIV-negative patient.
Simultaneous presentation of Kaposi sarcoma and HHV8-associated large B-cell lymphoma in the same lymph node: A rare diagnosis in an HIV-negative patient.
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DOI：
10.12659/ajcr.883980
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Lopes JM
中科院分区：
文献类型：
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作者：
Fernandes F;Eloy C;Carimo A;Pinto P;Graves S;Simões J;Carrilho C;Lopes JM
病人：女性，18岁最终诊断：同时出现卡波西肉瘤和淋巴瘤症状：-药物治疗：-临床程序：-专科：肿瘤罕见疾病KSHV/HHV-8与卡波西肉瘤（KS）以及几种淋巴组织增生性疾病有关，主要发生在HIV感染/AIDS患者中。虽然淋巴瘤和卡波西肉瘤之间的联系已经被描述，但在同一器官内同时存在这两种实体是罕见的，主要与艾滋病毒/艾滋病有关。我们报告的情况下，同时发生卡波西肉瘤和大B细胞淋巴瘤在同一个淋巴结在一个18岁的非洲妇女谁是艾滋病毒阴性。我们发现并发感染卡波西肉瘤疱疹病毒（KSHV）和EB病毒（EBV），证实了从石蜡块中选择的不同肿瘤区域获得的DNA的PCR扩增。对于进行细针穿刺细胞学（FNAC）评价的病理学家来说，在同一器官中发生2个具有不同特征的病变的可能性可能是意外的，但即使在HIV阴性个体中也必须考虑，尽管这种情况很少发生，正如本病例所证明的那样。
Patient: Female, 18 Final Diagnosis: Simultanous presentation of Kaposi Sarcoma and Lymphoma Symptoms: — Medication: — Clinical Procedure: — Specialty: Oncology Rare disease KSHV/HHV-8 is associated with Kaposi’s sarcoma (KS) as well as with a few categories of lymphoproliferative diseases, mostly occurring in patients with HIV infection/AIDS. Although the association between lymphomas and Kaposi’s sarcoma has been described, the simultaneous presence of the 2 entities within the same organ is rare and mainly associated with HIV/ AIDS. We report a case of simultaneous occurrence of Kaposi‘s sarcoma and large B-cell lymphoma in the same lymph node in a 18-year-old African woman who was HIV-negative. We found concurrent infection with Kaposi’s sarcoma herpes virus (KSHV) and Epstein-Barr virus (EBV), confirmed by PCR amplification of DNA obtained from distinct tumor areas selected in the paraffin block. The possibility of occurrence of 2 lesions with distinct features in the same organ may be unexpected for pathologists performing fine-needle aspiration cytology (FNAC) evaluation but must be considered, even in HIV-negative individuals, despite its rare occurrence, as was demonstrated by this case.