Current status of tertiary debulking surgery and prognosis after secondary debulking surgery for recurrent Mullerian epithelial cancer in Japan: a retrospective analysis of 164 patients (KCOG-G1402)
Current status of tertiary debulking surgery and prognosis after secondary debulking surgery for recurrent Mullerian epithelial cancer in Japan: a retrospective analysis of 164 patients (KCOG-G1402)
复制标题
DOI：
10.1186/s12957-017-1200-x
复制
发表时间：
2017-07-17
影响因子：
3.2
通讯作者：
Nasu, Kaei
中科院分区：
文献类型：
--
作者：
Hirakawa, Tomoko;Minaguchi, Takeo;Nasu, Kaei
背景资料：本研究旨在评估二次减积手术（SDS）和三次减积手术（TDS; SDS后复发）的现状，并评估日本苗勒上皮癌复发后的总生存率。我们还评估了接受第四次减积手术（即，方法：我们对164例复发性苗勒管上皮癌患者进行了回顾性研究。例如，卵巢癌、输卵管癌和腹膜癌）。SDS于2000年1月至2014年9月在20家日本医院进行。结果：164例患者中，66例在SDS治疗后无复发或死亡。98例患者在SDS后复发。98例患者中有43例接受了TDS; 98例患者中有55例未接受TDS，被归类为非TDS组。SDS后TDS组的总生存率（OS）明显优于非TDS组。TDS组和非TDS组SDS后的中位OS分别为123个月和42个月。在接受TDS的43例患者中，11例患者进一步接受QDS治疗。SDS后的中位OS为123个月的患者接受QDS.Conclusions：这多中心研究后SDS的预后显然是第一次报告QDS在日本。与非TDS组患者相比，接受TDS的患者预后良好。新的药物正在评估中;然而，减瘤手术仍然是复发的必要治疗方法。
Background: This study aimed to evaluate the current status of secondary debulking surgery (SDS) and tertiary debulking surgery (TDS; performed for recurrence after SDS) and to assess the overall survival after recurrence of Mullerian epithelial cancer in Jap. We also evaluated the data of patients who underwent a fourth debulking surgery (i.e., quaternary debulking surgery (QDS)).Methods: We conducted a retrospective study of 164 patients with recurrent Mullerian epithelial cance (i. e., ovarian, tubal, and peritoneal cancers). The SDS was performed between January 2000 and September 2014 in 20 Japanese hospitals. Clinicopathological data were collected and analyzed.Results: Of the 164 patients, 66 patients did not have a recurrence or died after SDS. Ninety-eight patients had a recurrence after SDS. Forty-three of the 98 patients underwent TDS; 55 of the 98 patients did not undergo TDS and were classified into the non-TDS group. The overall survival (OS) after SDS was significantly better in the TDS group than in the non-TDS group. The median OS after SDS was 123 and 42 months in the TDS group and non-TDS group, respectively. Of the 43 patients who received TDS, 11 patients were further treated with QDS. The median OS after SDS was 123 months for patients who underwent QDS.Conclusions: This multicenter study on the prognosis of post-SDS is apparently the first report on QDS in Japan. Patients undergoing TDS have a good prognosis, compared to patients in the non-TDS group. Novel drugs are being evaluated; however, debulking surgery remains a necessary treatment for recurrence.