Reduction of adhesion formation and promotion of wound healing after laminectomy by pharmacological inhibition of pro-inflammatory cytokines: an experimental study in the rat
Reduction of adhesion formation and promotion of wound healing after laminectomy by pharmacological inhibition of pro-inflammatory cytokines: an experimental study in the rat
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DOI：
10.1007/s00586-010-1488-5
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发表时间：
2010-12-01
影响因子：
2.8
通讯作者：
Olmarker, Kjell
中科院分区：
文献类型：
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作者：
Olmarker, Kjell
在之前对大鼠进行的 TNF 抑制实验中，意外发现与之前的经验相比，粘连和疤痕形成有所减少。伤口和骨骼的愈合似乎也得到了增强。本研究的目的是评估是否可以使用标准化的大鼠椎板切除术在受控环境中验证这一观察结果。五只大鼠接受强力霉素，另外五只大鼠接受盐水作为对照。椎板切除术后 1 周的宏观盲法评估显示，多西环素治疗动物的粘连和疤痕形成少于对照动物。研究发现，经过多西环素治疗的动物的伤口和骨骼愈合情况更好。观察到的作用机制尚无法完全理解，但数据表明，进一步的研究可能会带来设计药理学方式的机会，以减少粘连和疤痕形成，也许与适当的屏障相结合。
In a previous experiment using TNF inhibition in the rat it was accidentally found that adhesion and scar formation was reduced compared to previous experience. Wound and bone healing also seemed enhanced. The present study was conducted to assess if this observation could be verified in a controlled setting using a standardized laminectomy in the rat. Five rats received doxycycline and five other rats received saline and served as control. Macroscopic blinded evaluation 1 week after the laminectomy revealed that adhesion and scar formation was less in doxycycline-treated animals than in control animals. Wound and bone healing was found to be better in doxycycline-treated animals. The mechanisms for the observed effects cannot be fully understood but the data indicate that further research may lead to opportunities to design pharmacological modalities to reduce adhesion and scar formation, maybe in combination with suitable barriers.