Guiding DNA repair at the nuclear periphery.
Guiding DNA repair at the nuclear periphery.
复制标题
指导核外围的 DNA 修复。
DOI：
10.1038/s41556-023-01164-2
复制
发表时间：
2023
影响因子：
21.3
通讯作者：
Audibert S
中科院分区：
文献类型：
--
作者：
Audibert S
核膜参与DNA修复的空间调控，但其背后的机制尚不清楚。一项研究现在报告说，一种位于核内的核酸酶NUMEN/ENDOD 1通过抑制DNA末端的切除和异常重组来指导DNA修复途径的选择，从而确保基因组稳定性。
The nuclear envelope participates in the spatial regulation of DNA repair, but the mechanisms behind this are unclear. A study now reports that a nuclear envelope-localized nuclease, NUMEN/ENDOD1, guides the choice of DNA-repair pathway by inhibiting the resection of DNA ends and aberrant recombination, ensuring genome stability.