Occurrences of Three Classes of Antibiotics in a Natural River Basin: Association with Antibiotic-Resistant Escherichia coli
Occurrences of Three Classes of Antibiotics in a Natural River Basin: Association with Antibiotic-Resistant Escherichia coli
复制标题
天然河流流域中三类抗生素的出现：与抗生素耐药性大肠杆菌的关联
DOI：
10.1021/es503700j
复制
发表时间：
2014
影响因子：
11.4
通讯作者：
Hu JY
中科院分区：
文献类型：
--
作者：
Zhang Qinqin;Jia Ai;Wan Yi;Peng Hui;Dong Zhaomin;Hu Jianying;Zhang Qinqin;Liu Hong;Wang Kunping;Hu JY
调查城市河流中抗生素的检出情况及其与耐药大肠埃希菌、20种氟喹诺酮类抗生素、16种四环素类抗生素及其降解产物的关系。和25种磺胺类药物对温榆河及其支流的45个河水样品、13个污水样品和4个综合出水样品进行了降解产物的测定来自中国北京污水处理厂的样本。在河水中检测到15种荧光素、8种三氯甲烷（包括4种降解产物）和16种水杨酸（包括4种乙酰化产物）。河水中的主要抗生素为水杨酸类（总浓度达3164.0 ng/L），其次为氟喹诺酮类（1430.3 ng/L）和四环素类（296.6 ng/L）。在13个排放点样品中检测到的各类抗生素的总浓度高于河流样品中的浓度，其中SA为12326.7 ng/L，FQs为6589.2 ng/L，TC为730.1 ng/L，这在很大程度上导致了河流流域的高浓度。对数线性回归分析表明，温榆河流域水体中的氟喹诺酮类、三氯甲烷类和水杨酸类的浓度与大肠杆菌数量呈显著正相关。大肠杆菌对FQs（p< 0.05）、TC（p< 0.05）和SA（p< 0.05）耐药，为抗生素使用的环境影响提供了证据。
To investigate the occurrence of antibiotics in urban rivers and their association with antibiotic-resistantEscherichia coli, 20 (fluoro)quinolone antibiotics (FQs), 16 tetracycline antibiotics (TCs) and their degradation products, and 25 sulfonamides (SAs) and some degradation products were determined in 45 river samples and 13 discharged wastewater samples collected from Wenyu River and its tributaries and 4 composite effluent samples from sewage treatment plants in Beijing, China. Fifteen FQs, eight TCs, including four degradation chemicals, and sixteen SAs, including four acetylated products, were detected in the river water. The SAs were the dominant antibiotic (total concentrations up to 3164.0 ng/L) in river water, followed by FQs (1430.3 ng/L) and TCs (296.6 ng/L). The sum concentrations for each class of detected antibiotic in the 13 discharge site samples were higher than those in river samples, up to 12326.7 ng/L for SAs, 6589.2 ng/L for FQs, and 730.1 ng/L for TCs, largely contributing to the high concentrations in the river basin. Log–linear regression analysis confirmed that the concentrations of FQs, TCs, and SAs in the Wenyu River basin were strongly correlated with the number ofE. coliresistant to FQs (p< 0.05), TCs (p< 0.05), and SAs (p< 0.05), providing evidence for the environmental impacts of antibiotic usage.