Ritonavir boosted indinavir treatment as a simplified maintenance 'mono'-therapy for HIV infection
Ritonavir boosted indinavir treatment as a simplified maintenance 'mono'-therapy for HIV infection
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DOI：
10.1097/00002030-200404090-00017
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发表时间：
2004-04-09
期刊：
影响因子：
3.8
通讯作者：
Vernazza, PL
中科院分区：
文献类型：
--
作者：
Kahlert, C;Hupfer, M;Vernazza, PL
三联疗法是目前HIV治疗的基本概念。我们评估了利托那韦加强茚地那韦48周维持治疗12例HIV感染患者的可行性。所有患者在整个研究期间维持病毒抑制（< 50拷贝/ml）（32周后1例脱落），此后选择继续这种单一疗法。在第48周，使用双能X线吸收测量扫描未检测到脂肪分布模式的变化。这些结果支持进一步评价单维持试验。
Triple combination is currently the fundamental concept for HIV therapy. We evaluated the feasibility of a 48-week maintenance therapy with ritonavir-boosted indinavir in 12 HIV-infected patients. All patients maintained viral suppression (< 50 copies/ml) throughout the study (one drop-out after week 32) and opted to continue on this monotherapy thereafter. At week 48, no changes in fat distribution patterns were detectable using a dual-energy X-ray absorptiometry scan. These results support the further evaluation of mono-maintenance trials.