CD8+ T suppressor cells are back to the game: Are they players in autoimmunity?
CD8+ T suppressor cells are back to the game: Are they players in autoimmunity?
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DOI：
10.1016/s1568-9972(02)00065-4
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发表时间：
2002-10-01
影响因子：
13.6
通讯作者：
Suciu-Foca, Nicole
中科院分区：
文献类型：
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作者：
Filaci, Gilberto;Suciu-Foca, Nicole
在人类中发现的CD8+T抑制淋巴细胞属于三个不同的亚群。它们都能抑制抗原特异性T细胞的增殖。CD8+T抑制细胞的1型和2型以CD8+CD28型−表型为特征，而3型CD8+T抑制细胞的表型目前尚无详细数据。CD8+抑制型T淋巴细胞通过诱导树突状细胞表面共刺激分子表达的改变而发挥作用。需要细胞间的接触来调节这一效应。CD8+T抑制细胞2型通过分泌细胞因子(干扰素γ、白介素6)诱导抑制，不需要直接与抗原提呈细胞相互作用。CD8+T抑制细胞3型通过分泌IL10介导其功能。CD8+T抑制细胞亚群的复杂性和多样性提示，CD8+T抑制细胞可能与CD4+T调节细胞亚群一起在免疫稳态调节中发挥重要作用。为了更好地了解免疫系统、其功能以及在免疫介导性疾病过程中调节其活动的可能性，需要弄清免疫网络中这些抑制子/调节亚群的功能的特殊性。
The CD8+T suppressor lymphocytes identified in humans belong to three different subpopulations. All of them inhibit the proliferation of antigen-specific T cells. The type 1 and type 2 of CD8+T suppressor cells are characterized by the CD8+CD28−phenotype, while no detailed data are available at the moment on the phenotype of the type 3 of CD8+T suppressor cells. The type 1 of CD8+suppressor T lymphocytes acts by inducing alteration of expression of co-stimulatory molecules on dendritic cells. A cell-to-cell contact is required to mediate this effect. The type 2 of CD8+T suppressor cells induces inhibition via cytokine secretion (IFNγ, IL6) and do not need to interact directly with antigen presenting cells. The type 3 of CD8+T suppressor cells mediates its function through the secretion of IL10. The complexity and multiplicity of CD8+T suppressor cell subsets suggests that these cells may have an important role in the regulation of the immune homeostasis, acting together with the CD4+T regulatory cell subpopulations. The specificity of the functions of each of these suppressor/regulatory subsets in the immune network requires to be clarified to better understand the immune system, its functions and the possibilities to modulate its activities in the course of immune-mediated diseases.