Infarct size after reperfusion by simultaneous intracoronary In-111-monoclonal antimyosin and Tc-99mPyrophosphate: Comparison by gamma scintigraphy
Infarct size after reperfusion by simultaneous intracoronary In-111-monoclonal antimyosin and Tc-99mPyrophosphate: Comparison by gamma scintigraphy
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同时冠状动脉内 In-111-单克隆抗肌球蛋白和 Tc-99m 焦磷酸盐再灌注后的梗死面积：通过伽马闪烁扫描进行比较
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
E. Haber
中科院分区：
文献类型：
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作者：
B. Khaw;H. Gold;Richard H. Moore;J. Fallon;T. Yasuda;R. Leinbach;H. Strauss;E. Haber
为了确定 Tc-99m 标记的焦磷酸盐 (PYP) 和 In-111 标记的抗肌球蛋白 (AM) 是否可以识别急性心肌梗塞 (MI) 的相似区域，在 7 只狗中测定了它们的分布，并将结果与三苯基氯化四唑 (TTC) 测量的 MI 进行比较。对七只麻醉的开胸狗进行 3 小时的 LAD 闭塞。再灌注15分钟后，通过冠状动脉导管将4mCi的Tc-99m PYP和2mCi In-111 AM的混合物注入LAD。 45分钟后，狗被杀死；将心脏平行于房室沟切成0.5cm的切片，然后用TTC染色。使用配备中等能量准直器的伽马相机对 0.5 cm 切片进行成像，Tc-99m 为 140 KeV，In-111 为 260 KeV。切片的 Tc-99m 和 In-111 图像被归一化为具有最高强度的像素和放射性面积测量的面积。比较了 PYP 与 In-111 AM 的像素密度比 (P/A)。在6只具有小至中度TTC梗塞的狗中（像素数SD=1131±445），P/A=1.97±0.36（平均值±SD），而仅在具有大梗塞的狗中P/A=0.78（像素数=2159）。 TTC 染色的 MI 几乎与 AMmore » 描绘的 MI 相同，但比 PYP 描绘的损伤区域小。这些结果表明，在大面积梗塞中，AM 描绘的梗塞大约等于 PYP 梗塞。但在中小型梗塞中，可能存在大面积严重受损但可逆性损伤的心肌，PYP 描绘的 MI 面积大约是 AM 显示的两倍。比较这两个心肌受损区域可能会为描绘严重但可逆受影响的心肌提供重要信息。« less
To determine if Tc-99m labeled pyrophosphate (PYP) and In-111 labeled antimyosin (AM) identify similar zones of acute myocardial infarction (MI), their distribution was determined in 7 dogs, and the results compared to a triphenyl tetrazolium chloride (TTC) measurement of the MI. Seven anesthetized open chest dogs had a 3 hr LAD occlusion. After 15 min of reperfusion, a mixture of 4mCi of Tc-99m PYP and 2mCi In-111 AM was administered into the LAD via the coronary artery catheter. The dogs were killed 45 min later; the hearts sliced into 0.5cm sections parallel to the atrioventricular groove and then stained with TTC. The 0.5 cm slices were imaged with a gamma camera equipped with a medium energy collimator at 140 KeV for Tc-99m and 260KeV for In-111. The Tc-99m and In-111 images of the slices were normalized to the pixel with highest intensity and the area of radioactivity planimetered. Ratios of pixel density of PYP to In-111 AM (P/A) were compared. In 6 dogs with small to moderate TTC infarcts (No. pixels SD=1131 +- 445), P/A=1.97 +- 0.36 (mean +- SD), whereas P/A=0.78 only in a dog with a large infarct (No. pixels=2159). TTC stained MIs were almost identical to AMmore » delineated MIs but were smaller than PYP delineated areas of damage. These results indicated that in large infarcts, the AM delineated infarct is approximately equal to PYP infarct. But in small to medium size infarcts where a large zone of severely compromised but reversibly injured myocardium may exist, PYP delineated area of MI is approximately twice that shown by AM. Comparison of these 2 zones of myocardial compromise may provide important information for delineation of severely but reversibly effected myocardium.« less