The Gut Microbiota and Autism Spectrum Disorders.
The Gut Microbiota and Autism Spectrum Disorders.
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DOI：
10.3389/fncel.2017.00120
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发表时间：
2017
影响因子：
5.3
通讯作者：
Hagerman RJ
中科院分区：
文献类型：
--
作者：
Li Q;Han Y;Dy ABC;Hagerman RJ
胃肠道(GI)症状是自闭症谱系障碍(ASD)患者常见的共病，但其潜在机制尚不清楚。许多研究表明，自闭症患者的粪便菌群组成和肠道微生物组的代谢产物发生了变化。肠道微生物区系通过神经内分泌、神经免疫和自主神经系统影响大脑发育和行为。此外，肠道微生物区系异常与几种疾病有关，如炎症性肠病(IBD)、自闭症和情绪障碍。在这里，我们回顾了中枢神经系统和胃肠道(脑-肠轴)之间的双向相互作用，以及肠道微生物区系在中枢神经系统(CNS)和ASD中的作用。微生物组介导的治疗可能是一种安全有效的ASD治疗方法。
Gastrointestinal (GI) symptoms are a common comorbidity in patients with autism spectrum disorder (ASD), but the underlying mechanisms are unknown. Many studies have shown alterations in the composition of the fecal flora and metabolic products of the gut microbiome in patients with ASD. The gut microbiota influences brain development and behaviors through the neuroendocrine, neuroimmune and autonomic nervous systems. In addition, an abnormal gut microbiota is associated with several diseases, such as inflammatory bowel disease (IBD), ASD and mood disorders. Here, we review the bidirectional interactions between the central nervous system and the gastrointestinal tract (brain-gut axis) and the role of the gut microbiota in the central nervous system (CNS) and ASD. Microbiome-mediated therapies might be a safe and effective treatment for ASD.