Multifunctional ZnO/TiO2 nanoarray composite coating with antibacterial activity, cytocompatibility and piezoelectricity
Multifunctional ZnO/TiO2 nanoarray composite coating with antibacterial activity, cytocompatibility and piezoelectricity
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具有抗菌活性、细胞相容性和压电性的多功能ZnO/TiO2纳米阵列复合涂层
DOI：
10.1016/j.ceramint.2019.03.076
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发表时间：
2019-07-01
影响因子：
5.2
通讯作者：
Li, Hong
中科院分区：
文献类型：
--
作者：
Pang, Shumin;He, Yuan;Li, Hong
具有纳米结构的金属氧化物如氧化锌（ZnO）、二氧化钛（TiO 2）因其多功能性而被应用于生物医学领域。采用水热法和低温液相法制备了ZnO/TiO 2纳米阵列（nZnO/TiO 2）涂层。复合材料的颗粒直径不超过100 nm，在钛基体上组装成纳米阵列。体外抑菌实验表明，其对金黄色葡萄球菌和大肠杆菌的最大抑菌率分别可达99%和90%。nZnO/TiO 2涂层具有良好的细胞相容性和生物相容性，促进MC 3 T3-E1细胞的增殖和碱性磷酸酶（ALP）的表达。对nZnO/TiO 2薄膜的压电性能进行了初步研究。复合粒子的粒径越小，其抗菌性能、生物相容性和压电性能越好。在周期性负荷的刺激下，MC 3 T3-E1细胞的生长受到促进，ALP分泌增加。纳米ZnO/TiO 2复合涂层具有抗菌、成骨和智能刺激等功能，有望成为骨科植入物智能涂层的一种新材料。
Metal oxides with nanostructures such as zinc oxide (ZnO), titanium dioxide (TiO2) have been used in biomedical fields for their multifunctional properties. In this study, ZnO/TiO2 nanoarray (nZnO/TiO2) coatings were prepared via hydrothermal synthesis followed by low temperature liquid phase method. The particle size of the composites were no more than 100 nm in diameter, assembled into nanoarray on the Ti substrate. In vitro antibacterial experiments showed that the maximum bacteriostatic rate could reach 99% against Staphylococcus aureus and 90% against Escherichia coli, respectively. Moreover, the nZnO/TiO2 coatings were of cytocompatibility and biocompatibility, promoting the proliferation of MC3T3-E1 and the expression of alkaline phosphatase (ALP). The piezoelectric properties of nZnO/TiO2 coatings were preliminarily investigated. The smaller the size of the composite particle was, the better the antibacterial property, biocompatibility and piezoelectric properties were. Under the stimulation of the periodic loading, the growth of MC3T3-E1 was promoted, so the secretion of ALP was. The nZnO/TiO2 composite coating with antibacterial activity, osteogenesis and intellectual stimulation would be a promising smart coating for orthopedic implants.