Location of preganglionic neurons is independent of birthdate but is correlated to reelin-producing cells in the spinal cord.
Location of preganglionic neurons is independent of birthdate but is correlated to reelin-producing cells in the spinal cord.
复制标题
节前神经元的位置与出生日期无关，但与脊髓中产生 reelin 的细胞相关。
DOI：
10.1002/cne.20212
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Yip,JosephW
中科院分区：
文献类型：
--
作者：
Yip,YeePing;Zhou,Guangdou;Capriotti,Christine;Yip,JosephW
许多研究表明，在神经元发育过程中，神经元的出生日期似乎对其最终位置和身份有重大影响。我们过去的研究表明，缺乏thereelingene的小鼠的交感节前神经元（SPN）在脊髓中的异常位置定居。在本研究中，我们确定出生日期不是导致SPN在脊髓中位置异常的因素，在正常和reelermice中，SPN的神经发生期是相似的，并且SPN在脊髓中的最终位置与出生日期无关。此外，我们已经确定了至少两种类型的腹侧中间神经元，V1和V2，这是参与生产的Reelin和定位的SPN在脊髓中。J. Comp.神经元475：564-574，2004.© 2004 Wiley利斯公司
Many studies suggest that during neuronal development the birthdate of a neuron appears to have significant consequences for its ultimate location and identity. Our past study shows that sympathetic preganglionic neurons (SPN) in mice lacking thereelingene settle in abnormal positions in the spinal cord. In the present study we determined that birthdate is not a factor contributing to the abnormal position of SPN inreeler.In both normal andreelermice the period of neurogenesis of SPN was similar, and the final location of SPN in the spinal cord was independent of birthdate. Additionally, we have identified at least two types of ventral interneurons, V1 and V2, that are involved in the production of Reelin and the positioning of SPN in the spinal cord. J. Comp. Neurol. 475:564–574, 2004. © 2004 Wiley‐Liss, Inc.