Postweaning social isolation exacerbates neurotoxic effects of the NMDA receptor antagonist MK-801 in rats
Postweaning social isolation exacerbates neurotoxic effects of the NMDA receptor antagonist MK-801 in rats
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DOI：
10.1007/s00702-013-1049-2
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发表时间：
2013-11-01
影响因子：
3.3
通讯作者：
Gass, Peter
中科院分区：
文献类型：
--
作者：
Inta, Dragos;Renz, Peter;Gass, Peter
精神分裂症的谷氨酸假说认为NMDA受体功能低下是其重要的病理生理机制。在啮齿类动物中，NMDA受体拮抗剂与精神病样作用一起诱导皮质损伤。青春期的压力可以通过未知的机制引发精神分裂症。在这里，我们表明，在大鼠少年慢性隔离显着增加MK-801触发的热休克蛋白70，神经元损伤的标志物，在压后皮质的表达。这些数据表明，青少年压力和NMDA受体阻滞剂的累加效应，可能与精神分裂症。
The glutamate hypothesis of schizophrenia postulates NMDA receptor hypofunction as important pathophysiological mechanism. In rodents, NMDA receptor antagonists induce together with psychosis-like effects cortical injury. Stress during adolescence can trigger schizophrenia by unknown mechanisms. Here we show in rats that juvenile chronic isolation significantly increases MK-801-triggered expression of heat shock protein 70, a marker of neuronal injury, in the retrosplenial cortex. These data suggest an additive effect of juvenile stress and NMDA receptor blockade, with possible relevance for schizophrenia.