EFFECTS OF NALOXONE AND NALTREXONE ON LOCOMOTOR-ACTIVITY IN C57BL/6 AND DBA/2 MICE
EFFECTS OF NALOXONE AND NALTREXONE ON LOCOMOTOR-ACTIVITY IN C57BL/6 AND DBA/2 MICE
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DOI：
10.1016/0091-3057(82)90415-4
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发表时间：
1982-01-01
影响因子：
3.6
通讯作者：
PUGLISIALLEGRA, S
中科院分区：
文献类型：
--
作者：
CASTELLANO, C;PUGLISIALLEGRA, S
Administration of naloxone or naltrexone in DBA/2 (DBA) mice was followed by dose related depressant effects. The locomotor activity of the C57BL/ 6 (C57) mice injected with naltrexone was also depressed. Low doses of naloxone induced a decreased in activity in the C57 strain. This effect gradually disappeared at intermediate doses and recurred again at higher doses. The results are discussed in terms of differences in type, number and/or distribution of the receptors influenced by naloxone and naltrexone in the 2 strains of mice tested.
