SFTS Virus Infection in Nonhuman Primates
SFTS Virus Infection in Nonhuman Primates
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DOI：
10.1093/infdis/jiu564
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发表时间：
2015-03-15
影响因子：
6.4
通讯作者：
Li, Dexin
中科院分区：
文献类型：
--
作者：
Jin, Cong;Jiang, Hong;Li, Dexin
SFTS病毒（SFTSV）是一种高致病性布尼亚病毒，可引起严重发热伴血小板减少综合征（SFTS），这是中国的一种新发传染病。据报道，实验室小鼠对SFTSV感染易感，但对非人灵长类动物的感染尚未进行研究。这项研究首次报告了在恒河猴中，SFTSV不会引起严重症状或死亡，但会引起发热、血小板减少、白细胞减少以及血液中转氨酶和心肌酶水平升高。病毒血症，病毒特异性免疫球蛋白M和免疫球蛋白G抗体，中和抗体在所有感染的猕猴。血液中细胞因子干扰素γ、嗜酸性粒细胞趋化因子、肿瘤坏死因子α和巨噬细胞炎性蛋白1 β的水平显著升高。在感染后期，在肝脏和肾脏中观察到轻微的病理学病变。总体而言，恒河猴中的SFTSV感染与人类中的轻度SFTS相似。
SFTS virus (SFTSV) is a highly pathogenic bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease in China. Laboratory mice have been reported to be susceptible to SFTSV infection, but the infection in nonhuman primates has not been investigated. This study is the first to report that, in rhesus macaques, SFTSV does not cause severe symptoms or death but causes fever, thrombocytopenia, leukocytopenia, and increased levels of transaminases and myocardial enzymes in blood. Viremia, virus-specific immunoglobulin M and immunoglobulin G antibodies, and neutralizing antibodies were identified in all infected macaques. Levels of the cytokines interferon gamma, eotaxin, tumor necrosis factor alpha, and macrophage inflammatory protein 1 beta were significantly elevated in the blood. Minor pathological lesions were observed in the liver and kidney during the late stages of infection. Overall, SFTSV infection in rhesus macaques resembled mild SFTS in humans.