Neural stem cells as biological minipumps: a faster route to cell therapy for the CNS?
Neural stem cells as biological minipumps: a faster route to cell therapy for the CNS?
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DOI：
10.2174/157488807779317044
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发表时间：
2007
影响因子：
2.7
通讯作者：
H. Isaac Chen;Asha Bakshi;N. Royo;S. Magge;D. Watson;Nicolas C. Royo;Suresh N. Magge;Deborah J. Watson
中科院分区：
文献类型：
--
作者：
H. Isaac Chen;Asha Bakshi;N. Royo;S. Magge;D. Watson;Nicolas C. Royo;Suresh N. Magge;Deborah J. Watson
使用神经干细胞(NSCs)治疗神经疾病的一种策略是作为可移植的“生物微泵”，其中基因工程神经干细胞作为分泌治疗性(神经保护或抗肿瘤)药物的来源。神经干细胞在大脑中具有高度的流动性，并显示出对各种类型的中枢神经系统(CNS)病理的趋向性，使它们成为靶向基因输送载体的潜在候选者。虽然神经干细胞也被认为是一种潜在的替代神经元和星形胶质细胞的来源，以重新填充受损或退化的神经回路，但重建受损的大脑结构所涉及的挑战是巨大的，仍然是一个活跃的研究领域。相反，使用神经干细胞作为生物微泵并不依赖于神经元分化、轴突靶向或突触发生。这一策略可能是以细胞为基础的中枢神经系统治疗的更快途径，并准备进入人类临床试验。这篇综述考虑了两种类型的神经疾病，它们可能是NSC替代治疗的合适靶点：胶质脑瘤和创伤性脑损伤。我们研究了一些关键的科学和技术问题，这些问题必须解决，才能成功地将NSCs用作小型泵。
One strategy for the use of neural stem cells (NSCs) in treating neurological disorders is as transplantable "biological minipumps", in which genetically engineered neural stem cells serve as sources of secreted therapeutic (neuroprotective or tumoricidal) agents. Neural stem cells are highly mobile within the brain and demonstrate a tropism for various types of central nervous system (CNS) pathology, making them promising candidates for targeted gene delivery vehicles. Although neural stem cells have also been proposed as a potential source of replacement neurons and astrocytes to repopulate injured or degenerating neural circuits, the challenges involved in rebuilding damaged brain architecture are substantial and remain an active area of investigation. In contrast, the use of NSCs as biological minipumps does not rely on neuronal differentiation, axonal targeting, or synaptogenesis. This strategy may be a faster route to cell-based therapy of the CNS and is poised to move into human clinical trials. This review considers two types of neurologic disease that may be suitable targets for this alternative approach to NSC therapy: glial brain tumors and traumatic brain injury. We examine some of the key scientific and technical issues that must be addressed for the successful use of NSCs as minipumps.