Stress adaptation in a pathogenic fungus.
Stress adaptation in a pathogenic fungus.
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DOI：
10.1242/jeb.088930
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Leach MD
中科院分区：
文献类型：
--
作者：
Brown AJ;Budge S;Kaloriti D;Tillmann A;Jacobsen MD;Yin Z;Ene IV;Bohovych I;Sandai D;Kastora S;Potrykus J;Ballou ER;Childers DS;Shahana S;Leach MD
白色念珠菌是人类的主要真菌病原体。这种酵母被许多个体作为无害的共生体携带，但当免疫防御被扰乱时，它会引起粘膜感染(鹅口疮)。此外，当免疫系统严重受损时，白色念珠菌往往会引起危及生命的系统性感染。一系列毒力因子和健康属性促进了白念珠菌的致病性。适应性属性包括对局部环境压力的强烈反应，这种反应的失活会减弱毒力。白念珠菌的压力信号通路包括进化上保守的模块。然而，已经有一些压力调节回路的重新连接，使得一些调控因子在白色念珠菌中的作用相对于良性模式酵母酿酒酵母和裂殖酵母有所不同。这反映了白念珠菌作为一种与温血动物有关的机会性病原体的特定进化，与在不同环境生态位中发现的其他酵母相比。我们对白色念珠菌应激信号的理解主要基于葡萄糖培养的细胞对个别应激的体外反应。然而，在体内，这种病原体占据着复杂和动态的宿主生态位，其特点是替代碳源和同时暴露于组合应激(而不是单独的应激)。很明显，碳源的变化强烈地影响着抗逆性，并且一些组合胁迫对白色念珠菌产生非相加效应。这些效应与疾病进展过程中真菌-宿主的相互作用有关，由多种机制介导，包括信号和化学串扰、胁迫途径干扰和生物晶体管。
Candida albicans is a major fungal pathogen of humans. This yeast is carried by many individuals as a harmless commensal, but when immune defences are perturbed it causes mucosal infections (thrush). Additionally, when the immune system becomes severely compromised, C. albicans often causes life-threatening systemic infections. A battery of virulence factors and fitness attributes promote the pathogenicity of C. albicans. Fitness attributes include robust responses to local environmental stresses, the inactivation of which attenuates virulence. Stress signalling pathways in C. albicans include evolutionarily conserved modules. However, there has been rewiring of some stress regulatory circuitry such that the roles of a number of regulators in C. albicans have diverged relative to the benign model yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. This reflects the specific evolution of C. albicans as an opportunistic pathogen obligately associated with warm-blooded animals, compared with other yeasts that are found across diverse environmental niches. Our understanding of C. albicans stress signalling is based primarily on the in vitro responses of glucose-grown cells to individual stresses. However, in vivo this pathogen occupies complex and dynamic host niches characterised by alternative carbon sources and simultaneous exposure to combinations of stresses (rather than individual stresses). It has become apparent that changes in carbon source strongly influence stress resistance, and that some combinatorial stresses exert non-additive effects upon C. albicans. These effects, which are relevant to fungus–host interactions during disease progression, are mediated by multiple mechanisms that include signalling and chemical crosstalk, stress pathway interference and a biological transistor.
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影响因子：
3.4
作者：
Barelle CJ;Priest CL;Maccallum DM;Gow NA;Odds FC;Brown AJ
通讯作者：
Brown AJ
影响因子：
5.4
作者：
Brown, Alistair J. P.;Haynes, Ken;Quinn, Janet
通讯作者：
Quinn, Janet
影响因子：
3.7
作者：
Bruce CR;Smith DA;Rodgers D;da Silva Dantas A;MacCallum DM;Morgan BA;Quinn J
通讯作者：
Quinn J
影响因子：
2.8
作者：
Arana, DM;Nombela, C;Pla, J
通讯作者：
Pla, J
影响因子：
--
作者：
Chauhan, N;Inglis, D;Calderone, R
通讯作者：
Calderone, R