No Overlap among Serum GAD65, NMDAR and AQP4 Antibodies in Patients with Neuromyelitis Optica Spectrum Disorders
No Overlap among Serum GAD65, NMDAR and AQP4 Antibodies in Patients with Neuromyelitis Optica Spectrum Disorders
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DOI：
10.1159/000371492
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发表时间：
2015-01-01
影响因子：
2.4
通讯作者：
Cong, Gao
中科院分区：
文献类型：
--
作者：
Xie, Longchang;Long, Youming;Cong, Gao
目的：评价血清谷氨酸脱羧酶（GAD）、N-甲基-D-天冬氨酸受体（NMDAR）和水通道蛋白4（AQP 4）自身抗体是否在视神经肌萎缩症（NMO）/NMO谱系疾病（NMOSD）患者中共存。方法：收集98例NMO/NMOSD患者的血清标本。使用基于细胞的测定法测量血清GAD 65、NMDAR和AQP 4抗体。结果：63例（64.3%）患者有肌纤维化和视神经炎，符合修订后的NMO诊断标准。脊髓磁共振成像显示纵向广泛的横肌萎缩，26例患者（26.5%）显示至少3个椎体节段的连续T2加权信号异常; 5例患者（5.1%）有复发性视神经炎，4例患者（4.1%）有脑综合征伴视神经炎和肌萎缩。98名患者中无糖尿病、僵人综合征或癫痫。所有98例患者均检测出AQP 4抗体阳性。没有患者检测出GAD 65和NMDAR抗体阳性。结论：在本研究中，我们发现在NMO/NMOSD患者血清中没有同时存在GAD 65、NMDAR和AQP 4抗体。(C)2015 S. Karger AG，巴塞尔
Objective: To evaluate whether serum glutamic acid decarboxylase (GAD), N-methyl-D-aspartate-receptor (NMDAR), and aquaporin-4 (AQP4) autoantibodies coexist in patients with neuromyelitis optica (NMO)/NMO spectrum disorders (NMOSD). Methods: Serum samples were collected from 98 patients with NMO/NMOSD. Serum GAD65, NMDAR and AQP4 antibodies were measured using a cell-based assay. Results: A total of 63 patients (64.3%) had myelitis and optic neuritis and satisfied the revised diagnostic criteria for NMO. Longitudinally extensive transverse myelitis was seen on spinal cord magnetic resonance imaging, showing continuous T2-weighted signal abnormalities in at least three vertebral segments in 26 patients (26.5%); 5 patients (5.1%) had recurrent optic neuritis, and 4 patients (4.1%) had brain syndromes with optic neuritis and myelitis. None of the 98 patients had diabetes, stiff-man syndrome, or epilepsy. All 98 patients tested positive for AQP4 antibody. No patients tested positive for GAD65 and NMDAR antibodies. Conclusions: In the present study, we found no simultaneous presence of serum GAD65, NMDAR and AQP4 antibodies in patients with NMO/NMOSD. (C) 2015 S. Karger AG, Basel