Experimental assessment of resolution improvement of a zoom-in PET
Experimental assessment of resolution improvement of a zoom-in PET
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DOI：
10.1088/0031-9155/56/17/n01
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发表时间：
2011-09-07
影响因子：
3.5
通讯作者：
Cherry, Simon R.
中科院分区：
文献类型：
--
作者：
Qi, Jinyi;Yang, Yongfeng;Cherry, Simon R.
我们提出了一种放大正电子发射断层扫描 (PET) 系统，该系统将高分辨率探测器合并到现有 PET 扫描仪中，以获得感兴趣区域的高分辨率图像。之前我们通过计算机模拟表明，高分辨率探测器可以提高空间分辨率和病变可检测性方面的整体系统性能。在这项研究中，我们通过将高分辨率探测器集成到我们现有的 microPET II 扫描仪中，评估了实际系统中分辨率的提高。高分辨率探测器由 14 x 28 阵列 0.5 x 0.5 x 10 mm(3) 氧正硅酸镥闪烁体元件组成，放置在 microPET II 扫描仪的中心附近。它通过锥形光纤束耦合到两个 64 通道光电倍增管 (PMT)。 PMT 信号由 microPET II 扫描仪中的电子器件读出。将 15 μ Ci Na-22 点源放置在高分辨率探测器上方的不同位置。使用 microPET II 扫描仪单独测量的数据以及 microPET II 数据与高分辨率探测器数据相结合来重建图像。通过重建的点源获取的剖面显示，沿平行于高分辨率探测器表面的方向，半高全宽大幅减小。
We have proposed a zoom-in positron emission tomography (PET) system that incorporates a high-resolution detector into an existing PET scanner to obtain high-resolution images of a region of interest. Previously we have shown by computer simulations that the high-resolution detector can improve the overall system performance in terms of spatial resolution and lesion detectability. In this study, we assessed the resolution improvement in a real system by incorporating a high-resolution detector into our existing microPET II scanner. The high-resolution detector consists of a 14 x 28 array of 0.5 x 0.5 x 10 mm(3) lutetium oxyorthosilicate scintillator elements and is placed near the center of the microPET II scanner. It is coupled to two 64-channel photomultiplier tubes (PMTs) via tapered optical fiber bundles. The PMT signals were read out by the electronics in the microPET II scanner. A 15 mu Ci Na-22 point source was positioned at various locations above the high-resolution detector. Images were reconstructed using the data measured by the microPET II scanner alone and the microPET II data combined with the high-resolution detector data. Profiles taken through the reconstructed point sources show substantial reduction in full-width-at-half-maximum along the direction parallel to the face of the high-resolution detector.