Highly porous hydroxyapatite scaffolds with elongated pores using stretched polymeric sponges as novel template
Highly porous hydroxyapatite scaffolds with elongated pores using stretched polymeric sponges as novel template
复制标题
DOI：
10.1016/j.matlet.2009.05.017
复制
发表时间：
2009-08-15
影响因子：
3
通讯作者：
Kim, Hyoun-Ee
中科院分区：
文献类型：
--
作者：
Jo, In-Hwan;Shin, Kwan-Ha;Kim, Hyoun-Ee
本研究报道了一种采用长形聚合物海绵作为新型模板提高高孔羟基磷灰石（HA）支架抗压强度的简单方法。在该方法中，将具有各向同性孔隙的聚合物海绵在200℃下单轴拉伸至50%伸长率2小时，然后涂上HA浆液。将HA包覆海绵在800℃下热处理3 h以去除聚合物海绵，在1250℃下热处理3 h以烧结HA壁。制备的样品显示出高度各向异性的孔隙结构，孔隙的伸长方向与聚合物海绵的伸长方向平行。这种简单的方法允许高多孔支架在平行于孔隙延伸方向的76%的孔隙率下具有3.8 +/- 0.1 MPa的高抗压强度。(C) 2009 Elsevier B.V.版权所有
This study reports a simple way of improving the compressive strength of highly porous hydroxyapatite (HA) scaffolds by adopting elongated polymeric sponges as a novel template. In this method, as-received polymeric sponges with isotropic pores were stretched uniaxially to 50% elongation at 200 degrees C for 2 h, and then coated with a HA slurry. The HA-coated sponges were heat-treated at 800 degrees C for 3 h to remove the polymeric sponges and at 1250 degrees C for 3 h to sinter the HA walls. The fabricated samples showed a highly anisotropic pore structure with elongated pores parallel to the direction of the elongation of the polymeric sponge. This simple method allowed a highly porous scaffold to have a high compressive strength of 3.8 +/- 0.1 MPa at a porosity of 76% when tested parallel to the direction of pore elongation. (C) 2009 Elsevier B.V. All rights reserved.