A computationally efficient electrophysiological model of human ventricular cells
A computationally efficient electrophysiological model of human ventricular cells
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DOI：
10.1152/ajpheart.00731.2001
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发表时间：
2002-06-01
影响因子：
4.8
通讯作者：
Panfilov, AV
中科院分区：
文献类型：
--
作者：
Bernus, O;Wilders, R;Panfilov, AV
最近的实验和理论结果强调了心脏组织和整个心脏水平的折返性心律失常建模研究的重要性。我们介绍了通过重新制定单个人类心室细胞的 Priebe-Beuckelmann 模型而获得的六变量模型。重新构建的模型的数值计算速度比原始模型快 4.9 倍，并且更加稳定。它保留了不同频率下的动作电位形状、动作电位持续时间的恢复和传导速度的恢复。我们能够通过修改选定的离子电流来重现心外膜、心内膜和 M 细胞的主要特性。我们对二维人体心室组织片中的螺旋波行为进行了模拟研究，结果表明螺旋波的频率为 3.3 Hz，线性核心直径约为 50 毫米，旋转平均频率为 0.62 rad/s。仿真结果与实验数据一致。总之，所提出的模型适用于人体心室组织中折返现象的高效、准确研究。
Recent experimental and theoretical results have stressed the importance of modeling studies of reentrant arrhythmias in cardiac tissue and at the whole heart level. We introduce a six-variable model obtained by a reformulation of the Priebe-Beuckelmann model of a single human ventricular cell. The reformulated model is 4.9 times faster for numerical computations and it is more stable than the original model. It retains the action potential shape at various frequencies, restitution of action potential duration, and restitution of conduction velocity. We were able to reproduce the main properties of epicardial, endocardial, and M cells by modifying selected ionic currents. We performed a simulation study of spiral wave behavior in a two-dimensional sheet of human ventricular tissue and showed that spiral waves have a frequency of 3.3 Hz and a linear core of similar to50-mm diameter that rotates with an average frequency of 0.62 rad/s. Simulation results agreed with experimental data. In conclusion, the proposed model is suitable for efficient and accurate studies of reentrant phenomena in human ventricular tissue.