The association of current hormonal contraceptive use with type-specific HPV detection
The association of current hormonal contraceptive use with type-specific HPV detection
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DOI：
10.1136/sextrans-2011-050005
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发表时间：
2011-08-01
影响因子：
3.6
通讯作者：
Koutsky, Laura A.
中科院分区：
文献类型：
--
作者：
Ghanem, Khalil G.;Datta, S. Deblina;Koutsky, Laura A.
背景：激素避孕药（HC）使用时间的增加可能与浸润性宫颈癌的风险呈正相关。作者在7718名参加26项性传播疾病的妇女中检查了类型特异性人乳头瘤病毒（HPV）检测与当前HC使用之间的关系，结果HC使用与HPV-16检测之间存在相关性（口服避孕药使用者调整后的患病率比为1.34（95%CI 1.05至1.71），口服避孕药使用者调整后的患病率比为1.41（1.01 ~ 2.04）; HC使用与其他HPV类型或任何HPV的检测之间没有关联。结论需要进行纵向研究以更好地定义这种类型-特异性相关性及其临床意义。
Background Increased duration of hormonal contraceptive (HC) use may be positively associated with the risk of invasive cervical cancer.Methods This is a secondary analysis from the HPV Sentinel Surveillance Study. The authors examined the association between type-specific human papillomavirus (HPV) detection and current HC use among 7718 women attending 26 sexually transmitted disease, family planning and primary care clinics in the USA.Results There was an association between HC use and HPV-16 detection (adjusted prevalence rate ratio 1.34 (95% CI 1.05 to 1.71) for oral contraceptive users and 1.41 (1.01 to 2.04) for depot-medroxyprogesterone acetate users); there was no association between HC use and detection of other HPV types or any HPV overall.Conclusions Longitudinal studies are needed to better define this type-specific association and its clinical significance.