Sympathetic Motor Neuron Dysfunction is a Missing Link in Age-Associated Sympathetic Overactivity.
Sympathetic Motor Neuron Dysfunction is a Missing Link in Age-Associated Sympathetic Overactivity.
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交感运动神经元功能障碍是与年龄相关的交感神经过度活跃中缺失的一环。
DOI：
10.1101/2023.09.27.559800
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Vivas,Oscar
中科院分区：
文献类型：
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作者：
delaCruz,Lizbeth;Bui,Derek;Moreno,ClaudiaM;Vivas,Oscar
交感神经系统的过度活跃是衰老的标志。这种过度活动背后的细胞机制仍然知之甚少，大多数注意力都集中在可能的中枢神经系统成分上。在这项工作中，我们假设，老化也影响了周围交感神经节的运动神经元的功能。为了验证这一假设，我们比较了从年轻（12周），中年（64周）和老年（115周）小鼠的上级颈神经节分离的神经元的电生理反应和离子通道活性。这些方法表明，衰老确实影响交感运动神经元的内在特性，增加自发和诱发的放电反应。M电流的减少是年龄相关性兴奋过度的主要原因。因此，必须考虑年龄对交感神经反射运动成分的影响，作为交感神经过度活跃机制的关键部分。
Overactivity of the sympathetic nervous system is a hallmark of aging. The cellular mechanisms behind this overactivity remain poorly understood, with most attention paid to likely central nervous system components. In this work, we hypothesized that aging also affects the function of motor neurons in the peripheral sympathetic ganglia. To test this hypothesis, we compared the electrophysiological responses and ion-channel activity of neurons isolated from the superior cervical ganglia of young (12 weeks), middle-aged (64 weeks), and old (115 weeks) mice. These approaches showed that aging does impact the intrinsic properties of sympathetic motor neurons, increasing spontaneous and evoked firing responses. A reduction of M current emerged as a major contributor to age-related hyperexcitability. Thus, it is essential to consider the effect of aging on motor components of the sympathetic reflex as a crucial part of the mechanism involved in sympathetic overactivity.