Correlation of KIF3A and OVOL1, but not ACTL9, with atopic dermatitis in Chinese pediatric patients
Correlation of KIF3A and OVOL1, but not ACTL9, with atopic dermatitis in Chinese pediatric patients
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KIF3A 和 OVOL1（而非 ACTL9）与中国儿童特应性皮炎的相关性
DOI：
10.1016/j.gene.2015.06.068
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发表时间：
2015-10-25
期刊：
影响因子：
3.5
通讯作者：
Xu, Feng
中科院分区：
文献类型：
--
作者：
Kang, Zhihua;Li, Qiao;Xu, Feng
特应性皮炎（AD）是我国儿童最常见的慢性炎症性皮肤病。迄今为止，该人群中AD的遗传易感性尚未完全阐明。三个单核苷酸多态性先前与欧洲人的AD相关，rs2897442（KIF3A），rs479844（OVOL1）和rs2164983（ACTL9）。为了验证这三个SNP与中国儿童人群中AD的相关性，我们进行了一项病例对照研究，包括235例儿童AD患者和200名健康对照。我们在基因型和等位基因水平上证实了该人群中rs2897442和rs479844与AD的相关性。统计学分析表明，rs2897442的C等位基因与AD发病风险增加相关，而rs479844的A等位基因与AD发病风险降低相关。未发现rs2164983与AD之间存在相关性。我们的研究表明KIF3A和OVOL1参与了中国儿童人群中AD的发生。(C)2015 Elsevier B.V.版权所有。
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in Chinese pediatric patients. To date, the genetic susceptibility to AD in this population has not been fully clarified. Three single nucleotide polymorphisms have previously been associated with AD in Europeans, rs2897442 (KIF3A), rs479844 (OVOL1) and rs2164983 (ACTL9). To verify the correlation between AD and these three SNPs in the Chinese pediatric population, we conducted a case-control study including 235 pediatric patients with AD and 200 health controls. We confirmed the correlation between rs2897442 and rs479844 and AD in this population at both the genotype and allele levels. Statistical analysis showed that the C allele of rs2897442 is associated with an increased risk of developing AD, while the A allele of rs479844 is associated with a reduced risk. No correlation between rs2164983 and AD was identified. Our study indicates that KIF3A and OVOL1 are involved in the development of AD in the Chinese pediatric population. (C) 2015 Elsevier B.V. All rights reserved.