Fluorine-18-fluoromisonidazole radiation dosimetry in imaging studies.
Fluorine-18-fluoromisonidazole radiation dosimetry in imaging studies.
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发表时间：
1997-10
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通讯作者：
M. Graham;L. Peterson;J. Link;M. L. Evans;J. Rasey;W. Koh;J. Caldwell;K. Krohn
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作者：
M. Graham;L. Peterson;J. Link;M. L. Evans;J. Rasey;W. Koh;J. Caldwell;K. Krohn
未标记的氟罗米索硝唑 (FMISO)，用正电子发射体 18F 标记，是一种用于 PET 研究的有用缺氧显像剂，在肿瘤、心血管疾病和中风患者中具有潜在应用。方法 计算接受影像学检查的患者的辐射剂量，以帮助确定 FMISO-PET 成像的辐射风险。静脉注射[18F]FMISO后，在患者的血液样本和PET图像中测定了放射性的时间依赖性浓度。辐射吸收剂量是使用医学内部辐射剂量 (MIRD) 委员会的程序计算的，并考虑到基于个体患者观察到的活动分布的剂量变化。作为这项研究的一部分，我们还计算了大脑到眼睛的 S 值。使用 ICRP 60 权重计算有效剂量当量。结果 男性有效剂量当量为 0.013 mSv/MBq，女性有效剂量当量为 0.014 mSv/MBq。女性的个体器官剂量与男性没有不同。假设膀胱排尿间隔为 2 或 4 小时，接受最高剂量的关键器官是膀胱壁（排尿间隔为 2 小时的剂量为 0.021 mGy/MBq，排尿间隔为 0.029 mGy/MBq 的剂量为 4 小时）。结论 [18F]FMISO 的器官剂量与其他常用核医学测试相关的器官剂量相当，表明与本研究相关的潜在辐射风险在普遍接受的限度内。
UNLABELLED Fluoromisonidazole (FMISO), labeled with the positron emitter 18F, is a useful hypoxia imaging agent for PET studies, with potential applications in patients with tumors, cardiovascular disease and stroke. METHODS Radiation doses were calculated in patients undergoing imaging studies to help define the radiation risk of FMISO-PET imaging. Time-dependent concentrations of radioactivity were determined in blood samples and PET images of patients following intravenous injection of [18F]FMISO. Radiation absorbed doses were calculated using the procedures of the Medical Internal Radiation Dose (MIRD) committee, taking into account the variation in dose based on the distribution of activities observed in the individual patients. As part of this study we also calculated an S value for brain to eye. Effective dose equivalent was calculated using ICRP 60 weights. RESULTS Effective dose equivalent was 0.013 mSv/MBq in men and 0.014 mSv/MBq in women. Individual organ doses for women were not different from men. Assuming bladder voiding at 2- or 4-hr intervals, the critical organ that received the highest dose was the urinary bladder wall (0.021 mGy/MBq with 2-hr voiding intervals or 0.029 mGy/MBq with 4-hr voiding intervals). CONCLUSION The organ doses for [18F]FMISO are comparable to those associated with other commonly performed nuclear medicine tests and indicate that potential radiation risks associated with this study are within generally accepted limits.