Alteration of knee joint connective tissues during contracture formation in spastic rats after an experimentally induced spinal cord injury
Alteration of knee joint connective tissues during contracture formation in spastic rats after an experimentally induced spinal cord injury
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DOI：
10.1080/03008200701413512
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发表时间：
2007-01-01
影响因子：
2.9
通讯作者：
Tobimatsu, Yoshiko
中科院分区：
文献类型：
--
作者：
Moriyama, Hideki;Yoshimura, Osamu;Tobimatsu, Yoshiko
本研究旨在阐明痉挛发展后关节周围结缔组织的变化可能是挛缩的基础。16只Wistar大鼠脊髓损伤，16只大鼠为假手术或未手术。采用组织学、组织形态学、免疫组织化学和生化分析评估膝关节关节周围结缔组织。组织学结果显示，脊髓损伤膝关节屈曲挛缩，滑膜内膜较小，内膜下致密，关节后囊无纤维化，后囊脱位。滑膜内膜长度仅在后囊处缩短。ⅰ型和ⅲ型胶原的分布和表达均不受影响。脊髓损伤后挛缩以滑膜内膜粘连为特征。致密和紊乱的关节囊可能导致关节僵硬。关节周围结缔组织的改变表现出挛缩性发展后的特征。
This study was made to elucidate the changes in the periarticular connective tissue that can underlie the contracture after spasticity development. Sixteen Wistar rats underwent a spinal cord injury and 16 rats were either sham- or nonoperated. The periarticular connective tissue of the knee joint was assessed with histological, histomorphometric, immunohistochemical, and biochemical analyses. Histological results showed a smaller synovial intima, a dense subintima and posterior joint capsule without fibrosis, and a disarranged posterior capsule in the spinal cord-injured knees with the flexion contracture. The synovial intima length was shortened only at the posterior capsule. Neither the distribution nor expression of type I and III collagen was affected. Contractures after spinal cord injuries are characterized by synovial intima adhesions. A dense and disarranged capsule may lead to joint stiffness. The alteration of periarticular connective tissues exhibits properties characteristic of the contracture after spacticity development.