Roles of Hydrophilic Homopolymers on the Hydrophobic-Association-Induced Physical Gelling of Amphiphilic Block Copolymers in Water
Roles of Hydrophilic Homopolymers on the Hydrophobic-Association-Induced Physical Gelling of Amphiphilic Block Copolymers in Water
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DOI：
10.1021/ma7026484
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发表时间：
2008-08
期刊：
影响因子：
5.5
通讯作者：
Huanhua Zhang;Lin Yu;Jiandong Ding
中科院分区：
文献类型：
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作者：
Huanhua Zhang;Lin Yu;Jiandong Ding
最近，发现添加聚（乙二醇）（PEG）均聚物剂可显着降低由聚乳酸（乳酸 - 甘氨酸）（PLGA）（PLGA）（PLGA）（PLGA）和PEG与TGEL的“正常”现象不同，用于PEG和POLE（丙烯）的块状共聚物的PLUROCY水凝胶（PPG）。 PLGA-PEG-PEG-PLGA物理水凝胶作为一种可注射的生物材料，这是为什么添加亲水性均聚物的原因可能增强了疏水性诱导的诱导的二重块共聚物的疏水性诱导的物理凝胶。在本文中，在带有三个组成的PEG/PLGA块共聚物的水性系统中进行了检查。我们向我们前进，以考虑到随机的per ...
Recently, the addition of poly(ethylene glycol) (PEG) homopolymers was found to significantly lower the sol−gel transition temperature Tgel of the aqueous system of a block copolymer composed of poly(lactic acid-co-glycolic acid) (PLGA) and PEG, different from the “normal” phenomenon of a Tgel increase for Pluronic hydrogels of block copolymers of PEG and poly(propylene glycol) (PPG). While such an effect is useful for applications of PLGA−PEG−PLGA physical hydrogels as an injectable biomaterial, it is puzzling why the addition of a hydrophilic homopolymer probably enhances the hydrophobic-association-induced physical gelation of an amphiphilic block copolymer. A series of PEG homopolymers with different molecular weights and concentrations were examined in the aqueous systems of PEG/PLGA block copolymers with three compositions in the present paper. An immiscibility mechanism was put forward by us to account for the earlier spontaneous thermogelling under the assumption of the structure of a randomly per...