The role of the ubiquitination-proteasome pathway in breast cancer: ubiquitin mediated degradation of growth factor receptors in the pathogenesis and treatment of cancer.
The role of the ubiquitination-proteasome pathway in breast cancer: ubiquitin mediated degradation of growth factor receptors in the pathogenesis and treatment of cancer.
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泛素化 - 促炎途径在乳腺癌中的作用：泛素介导的生长因子受体在癌症的发病机理和治疗中的降解。
DOI：
10.1186/bcr541
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发表时间：
2003
影响因子：
7.4
通讯作者：
Lipkowitz, S
中科院分区：
文献类型：
--
作者：
Lipkowitz, S
生长因子受体的异常活性与多种恶性肿瘤的发病机制有关。生长因子受体对信号的负调控在很大程度上是通过激活的受体的泛素化、内化和降解来介导的。在过去的几年里，对控制受体下调的机制已经有了相当大的了解。也有数据表明，导致抑制生长因子受体下调的突变可能在癌症的发病机制中发挥作用。旨在促进生长因子受体降解的治疗方法为恶性肿瘤的治疗提供了一条有希望的途径。
Aberrant activity of growth factor receptors has been implicated in the pathogenesis of a wide variety of malignancies. The negative regulation of signaling by growth factor receptors is mediated in large part by the ubiquitination, internalization, and degradation of the activated receptor. Over the past few years, considerable insight into the mechanisms that control receptor downregulation has been gained. There are also data suggesting that mutations that lead to inhibition of downregulation of growth factor receptors could play a role in the pathogenesis of cancer. Therapies directed at enhancing the degradation of growth factor receptors offer a promising approach to the treatment of malignancies.
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影响因子：
2.7
作者：
BAKER, A;CACHIA, P;PADUA, RA
通讯作者：
PADUA, RA
影响因子：
4.8
作者：
Ettenberg, SA;Magnifico, A;Lipkowitz, S
通讯作者：
Lipkowitz, S
影响因子：
19
作者：
Hicke, L
通讯作者：
Hicke, L
影响因子：
8
作者：
Bisson, SA;Ujack, EE;Robbins, SM
通讯作者：
Robbins, SM
影响因子：
11.4
作者：
Citri, A;Alroy, I;Yarden, Y
通讯作者：
Yarden, Y