Hippo signaling suppresses tumor cell metastasis via a Yki- Src42A positive feedback loop
Hippo signaling suppresses tumor cell metastasis via a Yki- Src42A positive feedback loop
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DOI：
10.1038/s41419-021-04423-y
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Zhou Zizhang
中科院分区：
文献类型：
--
作者：
Ding Yan;Wang Guiping;Zhan Meixiao;Sun Xiaohan;Deng Yanran;Zhao Yunhe;Liu Bin;Liu Qingxin;Wu Shian;Zhou Zizhang
Metastasis is an important cause of death from malignant tumors. It is of great significance to explore the molecular mechanism of.metastasis for the development of anti-cancer drugs. Here, we find that the Hippo pathway hampers tumor cell metastasis in vivo..Silence of hpo or its downstream wts promotes tumor cell migration in a Yki-dependent manner. Furthermore, we identify that.inhibition of the Hippo pathway promotes tumor cell migration through transcriptional activating src42A, a Drosophila homolog of.the SRC oncogene. Yki activates src42A transcription through direct binding its intron region. Intriguingly, Src42A further increases.Yki transcriptional activity to form a positive feedback loop. Finally, we show that SRC is also a target of YAP and important for YAP.to promote the migration of human hepatocellular carcinoma cells. Together, our findings uncover a conserved Yki/YAP-Src42A/.SRC positive feedback loop promoting tumor cell migration and provide SRC as a potential therapeutic target for YAP-driven.metastatic tumors.
