Functional neuroimaging of cerebellar activation during single word reading and verb generation in stuttering and nonstuttering adults
Functional neuroimaging of cerebellar activation during single word reading and verb generation in stuttering and nonstuttering adults
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DOI：
10.1016/s0304-3940(01)01671-8
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发表时间：
2001-04-20
影响因子：
2.5
通讯作者：
Houle, S
中科院分区：
文献类型：
--
作者：
De Nil, LF;Kroll, RM;Houle, S
口吃的成年人通常在流利和不流利的讲话中观察到发音不协调，这表明在言语产生所需的准确时间方面存在潜在的缺陷。口吃成年人的正电子发射断层扫描显示，与非口吃对照受试者相比，治疗前小脑的激活程度通常更高。强化流畅治疗导致小脑在治疗后立即阅读时的激活增加，并在1年后的扫描中降至接近正常水平。相比之下，动词生成导致了三次扫描中逐渐但一致的下降。这些结果表明，言语产生过程中运动和认知过程的自动性可能需要被认为是未来口吃研究的一个重要因素。(C)2001爱思唯尔爱尔兰科学有限公司。保留所有权利。
Articulatory discoordinations typically observed in fluent and disfluent speech of stuttering adults suggest an underlying deficiency in the precise timing needed for speech production. Positron emission tomography scans of stuttering adults showed generally higher cerebellar activations pre-treatment compared to nonstuttering control subjects. Intensive fluency treatment resulted in increased cerebellar activation during reading immediately post-treatment and a decrease to near normal levels at the 1 year follow scan. In contrast, verb generation resulted in a gradual but consistent decrease over the three scans. The results suggest that automaticity in motor and cognitive processes during speech production may need to be considered as an important factor in future investigations of stuttering. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.