GENETIC NOMENCLATURE FOR LOCI CONTROLLING MOUSE LYMPHOCYTE ANTIGENS
GENETIC NOMENCLATURE FOR LOCI CONTROLLING MOUSE LYMPHOCYTE ANTIGENS
复制标题
DOI：
10.1007/bf00364270
复制
发表时间：
1987-01-01
期刊：
影响因子：
3.2
通讯作者：
HAMMERLING, U
中科院分区：
文献类型：
--
作者：
MORSE, HC;SHEN, FW;HAMMERLING, U
现在有超过50种血清学定义的小鼠淋巴细胞表面抗原。其中，超过三十个是多态的，并已被证明是由一个单一的遗传位点控制。这些基因座大多用符号“ly”来表示，后面跟着一个或多或少按照基因座发现的顺序分配的数字（表1）。然而，没有一种机制可以有序地分配符号或数字，从而使用各种符号，重复数字，以及在同一位点使用不同的符号或数字。作者最近在马里兰州贝塞斯达的国家卫生研究院会面，讨论克服这些问题的方法。已编制了一份Ly位点命名准则的初步草案，并在同事间分发。在本文中，我们提出了一个修订版本的规则，其中我们(1)重新分配重复的Ly编号，(2)提供Ly位点的定义，以及(3)建立一个中央Ly命名注册中心，负责协调新Ly编号的分配。在建立这一命名法时，我们试图维持现状，只是重新分配了重复的编号或重命名了具有严重误导性名称的基因座，以便对现有系统造成最小程度的改变。例如，Lna，
There are now over fifty serologically defined mouse lymphocyte cell-surface antigens. Of these, more than thirty are polymorphic and have been shown to be controlled by a single genetic locus. These loci have mostly been designated by the symbol Ly-followed by a number assigned more or less in order of discovery of the locus (Table 1). However, there has been no mechanism for orderly assignment of symbols or numbers, with consequent use of a variety of symbols, duplication of numbers, and use of different symbols or numbers for the same locus. The authors recently met at the National Institutes of Health, Bethesda, Maryland, to discuss means of overcoming these problems. A preliminary draft of nomenclature hales for the Ly loci was prepared and circulated among colleagues. In this paper we present a revised version of the rules in which we (1) reallocate duplicated Ly numbers,(2) provide a definition of Ly loci, and (3) establish a central Ly nomenclature registry that will be responsible for coordinating the allocation of new Ly numbers. In establishing this nomenclature, we have tried to maintain the status quo and have only reallocated duplicated numbers or renamed loci with grossly misleading names in order to cause minimum alteration of the existing system. Thus, for example, Lna,