Lanthanide coordination polymer probe for time-gated luminescence sensing of pH in undiluted human serum.
Lanthanide coordination polymer probe for time-gated luminescence sensing of pH in undiluted human serum.
复制标题
用于未稀释人血清中 pH 值的时间选通发光传感的镧系元素配位聚合物探针。
DOI：
10.1016/j.talanta.2016.07.028
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发表时间：
2017
期刊：
影响因子：
6.1
通讯作者：
Xu Maotian
中科院分区：
文献类型：
--
作者：
Huang Yankai;Liu Baoxia;Shen Qi;Zhu Xu;Hao Yuanqiang;Chang Zhu;Xu Fang;Qu Peng;Xu Maotian
镧系配位聚合物（lcp）由于其特殊的结构和性能而成为一种令人着迷的材料。本研究以鸟苷-5′-单磷酸鸟苷（GMP）水溶性生物分子为桥接剂，镧系铽离子（Tb3+）为金属节点，银离子（Ag+）为增敏剂，合成了pH响应型的Tb/GMP/Ag发光镧系CP探针。由于Ag+的敏化作用，探针具有较高的发光强度；而在碱性溶液中，Tb/GMP/Ag中的Ag+立即与OH−结合，形成Ag2O沉淀，导致Tb/GMP/Ag明显的荧光猝灭。该探针对OH -具有较高的选择性，pH检测范围为7.5-13.0。此外，基于Tb/GMP/Ag在血清中具有较高的抗干扰能力，我们采用Tb/GMP/Ag对未稀释的人血清样品进行pH测量，结果令人满意。
Lanthanide coordination polymers (LCPs) have emerged as fascinating materials because of their specific structure and properties. In this work, utilizing hydrosoluble biomolecule of guanosine-5′-monophosphate (GMP) as bridging linker, lanthanide terbium ions (Tb3+) as metal nodes, and silver ions (Ag+) as sensitizers, we synthesized a pH responsive luminescent lanthanide CP probe of Tb/GMP/Ag. The probe possesses high luminescence due to the sensitization of Ag+; While in alkaline solutions, Ag+in Tb/GMP/Ag immediately binds to OH−, forming Ag2O precipitation and resulting in a distinct fluorescence quenching of Tb/GMP/Ag. This probe displays high selectivity for OH−and a broader pH detection range of 7.5–13.0. In addition, based on the high anti-interference ability in serum, we applied Tb/GMP/Ag to measure pH in undiluted human serum samples, yielding satisfactory results.